Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH2 | P48735 | 5/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CCR2 | P41597 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 5/20 | 0.33 |
| ▸ | RAF1 | P04049 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365570 | 0.85 | CA2 (0.37) | IDH2SCN9AKDM4EUSP2LMNA | |
| SCHEMBL17618886 | 0.85 | CA2 (0.37) | IDH2SCN9AKDM4EUSP2LMNA | |
| SCHEMBL19670369 | 0.84 | NAMPT (0.41) | IDH2KDM4ETSHRCA2CA9 | |
| SCHEMBL19669054 | 0.84 | NAMPT (0.41) | IDH2KDM4ETSHRCA2CA9 | |
| SCHEMBL16250024 | 0.84 | NAMPT (0.41) | IDH2KDM4ETSHRCA2CA9 | |
| SCHEMBL16250004 | 0.83 | MAPT (0.35) | IDH2TRPV1KDM4EUSP2LMNA | |
| Hydrochloric Acid SCHEMBL17770586 | 0.82 | NAMPT (0.39) | SCN9AKDM4ECA2CA9MAPT | |
| SCHEMBL17618888 | 0.80 | NAMPT (0.42) | SCN9ATSHRCA2CA9KMT2A | |
| SCHEMBL17624574 | 0.80 | MAPT (0.36) | BRAFRAF1MAPTMEN1ALDH1A1 | |
| SCHEMBL17618878 | 0.79 | IDH2 (0.42) | IDH2TRPV1KDM4EUSP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997029-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2019-01-09 | — | — | EP | disclosed |