Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 15/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 15/20 | 0.34 |
| ▸ | PHGDH | O43175 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20632750 | 0.84 | GRIN1 (0.37) | — | |
| SCHEMBL20632490 | 0.84 | DYRK1A (0.32) | PRMT5WDR77PHGDHCYP11B2 | |
| SCHEMBL20633055 | 0.84 | FYN (0.32) | CYP11B2 | |
| SCHEMBL20631643 | 0.83 | HTR2C (0.41) | PRMT5WDR77 | |
| SCHEMBL20632327 | 0.82 | FYN (0.32) | CYP11B2 | |
| SCHEMBL20632292 | 0.82 | HTR2C (0.41) | PHGDHCYP11B2 | |
| SCHEMBL20631589 | 0.79 | PHGDH (0.35) | PHGDH | |
| SCHEMBL20632922 | 0.78 | KDM4E (0.36) | — | |
| SCHEMBL20632763 | 0.78 | CYP11B2 (0.35) | CYP11B2 | |
| SCHEMBL20632941 | 0.78 | CYP11B2 (0.33) | CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997029-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2019-01-09 | — | — | EP | disclosed |