Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.34 |
| ▸ | TBK1 | Q9UHD2 | 5/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.30 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.30 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20632999 | 0.86 | JAK2 (0.32) | DYRK1AGSK3B | |
| SCHEMBL20633271 | 0.84 | RAB9A (0.38) | DYRK1AGSK3B | |
| SCHEMBL20631607 | 0.83 | DYRK1A (0.36) | CYP11B2CYP11B1DYRK1AGSK3B | |
| SCHEMBL20632736 | 0.82 | CDK5 (0.33) | CYP11B2LRRK2 | |
| SCHEMBL20632434 | 0.82 | GAA (0.39) | DYRK1AGSK3B | |
| SCHEMBL20632418 | 0.81 | CYP11B2 (0.33) | CYP11B2DYRK1AGSK3B | |
| SCHEMBL20633366 | 0.80 | RAB9A (0.33) | DYRK1AGSK3B | |
| SCHEMBL20632756 | 0.79 | KMT2A (0.33) | DYRK1AGSK3B | |
| SCHEMBL20632941 | 0.79 | CYP11B2 (0.33) | CYP11B2DYRK1AGSK3B | |
| SCHEMBL20632255 | 0.78 | MEN1 (0.43) | TRPV3GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997029-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2019-01-09 | — | — | EP | disclosed |