Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM2 | Q9P1W9 | 10/20 | 0.45 |
| ▸ | PIM1 | P11309 | 7/20 | 0.45 |
| ▸ | PIM3 | Q86V86 | 6/20 | 0.45 |
| ▸ | GSK3B | P49841 | 3/20 | 0.41 |
| ▸ | PRKCA | P17252 | 2/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | RBP4 | P02753 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | WNT3A | P56704 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17618461 | 0.90 | PIM2 (0.48) | PIM2PIM1PIM3GSK3BPRKCA | |
| SCHEMBL19670232 | 0.75 | PIM2 (0.43) | PIM2PIM1PIM3GSK3BPRKCA | |
| SCHEMBL17618443 | 0.75 | TRPV1 (0.49) | PIM2PIM1PIM3GSK3BPRKCA | |
| SCHEMBL17618436 | 0.75 | TRPV1 (0.41) | PIM2PIM1PIM3GSK3BPRKCA | |
| SCHEMBL16238183 | 0.75 | RPS6KB1 (0.39) | GSK3A | |
| SCHEMBL17618460 | 0.73 | CYP2C19 (0.37) | PIM2PIM3CYP2C19 | |
| SCHEMBL17618404 | 0.72 | TRPV1 (0.42) | PIM2PIM1PIM3GSK3BTRPV1 | |
| SCHEMBL17618462 | 0.71 | ABL1 (0.41) | DYRK1A | |
| SCHEMBL17618360 | 0.71 | GRM5 (0.37) | PIM2PIM1PIM3TRPV1 | |
| SCHEMBL19365347 | 0.71 | BTK (0.36) | PIM2PIM1PIM3TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997029-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2019-01-09 | — | — | EP | disclosed |