Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.43 |
| ▸ | PIM1 | P11309 | 3/20 | 0.43 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | PRKCA | P17252 | 1/20 | 0.39 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | RBP4 | P02753 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 3/20 | 0.34 |
| ▸ | HTR2C | P28335 | 3/20 | 0.34 |
| ▸ | HTR2B | P41595 | 2/20 | 0.34 |
| ▸ | SMO | Q99835 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16775948 | 0.85 | PIM2 (0.40) | PIM2PIM1PIM3TRPV1GSK3B | |
| SCHEMBL19670374 | 0.84 | TRPV1 (0.48) | PIM2PIM1PIM3TRPV1 | |
| SCHEMBL17618461 | 0.83 | PIM2 (0.48) | PIM2PIM1PIM3TRPV1GSK3B | |
| SCHEMBL19670377 | 0.83 | CRACR2A (0.35) | BRD4CREBBP | |
| SCHEMBL19670236 | 0.81 | DHODH (0.40) | CYP2C9HTR2C | |
| SCHEMBL19670155 | 0.79 | HDAC2 (0.36) | SLC22A12KDM4EALDH1A1HTTBRD4 | |
| SCHEMBL19670423 | 0.79 | TRPV3 (0.38) | PIM2PIM3TRPV1KDM4EALDH1A1 | |
| SCHEMBL19670368 | 0.78 | FGFR4 (0.39) | TRPV1TDP1RBP4CYP2C19KDM4E | |
| SCHEMBL19365457 | 0.77 | MAPT (0.38) | PIM2PIM1TRPV1GSK3BPRKCA | |
| SCHEMBL19670220 | 0.76 | ROCK2 (0.34) | TRPV1BRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |