Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cefixime. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APAF1 | O14727 | 2/20 | 1.00 |
| ▸ | PSMD14 | O00487 | 1/20 | 1.00 |
| ▸ | MMP2 | P08253 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 8/20 | 0.98 |
| ▸ | APEX1 | P27695 | 3/20 | 0.98 |
| ▸ | LMNA | P02545 | 2/20 | 0.98 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.98 |
| ▸ | TSHR | P16473 | 1/20 | 0.98 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.98 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.98 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.98 |
| ▸ | MAPT | P10636 | 4/20 | 0.78 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.78 |
| ▸ | CNR1 | P21554 | 1/20 | 0.78 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.78 |
| ▸ | NR1I2 | O75469 | 5/20 | 0.63 |
| ▸ | HTR2C | P28335 | 1/20 | 0.63 |
| ▸ | PPARG | P37231 | 2/20 | 0.60 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.60 |
| ▸ | SLC22A8 | Q8TCC7 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cefixime SCHEMBL7718771 | 1.00 | APAF1 (1.00) | APAF1PSMD14MMP2TDP1APEX1 | |
| Cefixime SCHEMBL27735290 | 1.00 | APAF1 (1.00) | APAF1PSMD14MMP2TDP1APEX1 | |
| Cefixime SCHEMBL2283413 | 1.00 | APAF1 (1.00) | APAF1PSMD14MMP2TDP1APEX1 | |
| Cefixime SCHEMBL7718769 | 1.00 | APAF1 (1.00) | APAF1PSMD14MMP2TDP1APEX1 | |
| Cefixime SCHEMBL28463175 | 1.00 | APAF1 (1.00) | APAF1PSMD14MMP2TDP1APEX1 | |
| Cefixime SCHEMBL3553111 | 0.99 | TDP1 (1.00) | APAF1PSMD14MMP2TDP1APEX1 | |
| Cefixime SCHEMBL4812946 | 0.99 | TDP1 (1.00) | APAF1PSMD14MMP2TDP1APEX1 | |
| Cefixime SCHEMBL17131963 | 0.99 | TDP1 (1.00) | APAF1PSMD14MMP2TDP1APEX1 | |
| Cefixime SCHEMBL9483204 | 0.99 | TDP1 (1.00) | APAF1PSMD14MMP2TDP1APEX1 | |
| Cefixime SCHEMBL12374914 | 0.99 | TDP1 (1.00) | APAF1PSMD14MMP2TDP1APEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 205 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021234724-A1 | Pharmaceutical formulation containing stable granules of clavulanic acid | TWENTY FIRST CENTURY PHARMACEUTICALS PVT. LTD. (IN) | 2021-11-25 | — | — | WO | claimed |
| CN-109734726-B | Refining method of cefixime trihydrate crystals | 山东省分析测试中心 | 2020-09-15 | — | — | CN | claimed |
| CN-104419766-B | Method for determining the presence or absence of shiga toxin-producing escherichia coli (STEC) in a food sample | 帕尔基因盘技术公司 | 2020-07-10 | — | — | CN | claimed |
| EP-2843057-B1 | Method for determining the presence or absence of shiga toxin-producing Escherichia coli (STEC) in a food sample | PALL GENEDISC TECH (FR) | 2017-12-27 | — | — | EP | claimed |
| CN-104693217-B | Method for preparing cefixime | 浙江华方药业股份有限公司 | 2017-01-11 | — | — | CN | claimed |
| CN-104004003-B | Cefixime derivative and its production and use | GUANGZHOU BAIYUNSHAN PHARMACEUTICAL HOLDINGS CO., LTD., BAIYUNSHAN PHARMACEUTICAL GENERAL FACTORY (CN) | 2016-05-25 | — | — | CN | claimed |
| CN-103980292-B | The crystallization method of cefixime trihydrate | Hangzhou Lingye Pharmaceutical Technology Co.,Ltd. (CN) | 2016-01-27 | — | — | CN | claimed |
| US-9233112-B2 | Pharmaceutical compositions of cefixime | LUPIN LIMITED (IN) | 2016-01-12 | — | — | US | claimed |
| US-9149482-B2 | Pharmaceutical formulation of cefixime for enhanced bioavailability | LUPIN LTD. (IN) | 2015-10-06 | — | — | US | claimed |
| CN-104693217-A | Method for preparing cefixime | ZHEJIANG HUAFANG PHARMACEUTICAL CO LTD | 2015-06-10 | — | — | CN | claimed |
| WO-2007119249-A2 | PHARMACEUTICAL COMPOSITIONS OF CEFIXIME | LUPIN LIMITED (IN) | 2007-10-25 | — | — | WO | claimed |
| WO-2006103686-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF CEFIXIME | HETERO DRUGS LIMITED (IN) | 2006-10-05 | — | — | WO | claimed |
| EP-1681050-A1 | Dispersible sustained release pharmaceutical compositions | Strides Arcolab Limited (IN) | 2006-07-19 | — | — | EP | claimed |
| WO-2005107703-A1 | NOVEL PHARMACEUTICAL FORMULATION OF CEFIXIME FOR ENHANCED BIOAVAILABILITY | LUPIN LTD. (IN) | 2005-11-17 | — | — | WO | claimed |
| EP-1566176-A1 | Synergistic antibacterial formulation and a method of making the same | Khandelwal, Sanjeev Prem Nivas (IN) | 2005-08-24 | — | — | EP | claimed |
| US-20050181051-A1 | Synergistic antibacterial formulation and to a method of making the same | KHANDELWAL SANJEEV (IN) | 2005-08-18 | — | — | US | claimed |
| US-20040005361-A1 | Pharmaceutical preparations | KHANDELWAL SANJEEV (IN) | 2004-01-08 | — | — | US | claimed |
| EP-0763043-B1 | PROCESS FOR THE PREPARATION OF TRIHYDRATED CEFIXIME | MARCHAM TRADING & INVESTMENT L (IE) | 1998-09-23 | — | — | EP | claimed |
| EP-0763043-A1 | PROCESS FOR THE PREPARATION OF TRIHYDRATED CEFIXIME | MARCHAM TRADING & INVESTMENT LTD. (IE) | 1997-03-19 | — | — | EP | claimed |
| WO-1995033753-A1 | PROCESS FOR THE PREPARATION OF TRIHYDRATED CEFIXIME | MARCHAM TRADING & INVESTMENT LTD. (IE) | 1995-12-14 | — | — | WO | claimed |