Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cefixime. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APAF1 | O14727 | 2/20 | 1.00 |
| ▸ | PSMD14 | O00487 | 1/20 | 1.00 |
| ▸ | MMP2 | P08253 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 8/20 | 0.98 |
| ▸ | APEX1 | P27695 | 3/20 | 0.98 |
| ▸ | LMNA | P02545 | 2/20 | 0.98 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.98 |
| ▸ | TSHR | P16473 | 1/20 | 0.98 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.98 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.98 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.98 |
| ▸ | MAPT | P10636 | 4/20 | 0.78 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.78 |
| ▸ | CNR1 | P21554 | 1/20 | 0.78 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.78 |
| ▸ | NR1I2 | O75469 | 5/20 | 0.63 |
| ▸ | HTR2C | P28335 | 1/20 | 0.63 |
| ▸ | PPARG | P37231 | 2/20 | 0.60 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.60 |
| ▸ | SLC22A8 | Q8TCC7 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cefixime SCHEMBL7718771 | 1.00 | APAF1 (1.00) | APAF1PSMD14MMP2TDP1APEX1 | |
| Cefixime SCHEMBL2283413 | 1.00 | APAF1 (1.00) | APAF1PSMD14MMP2TDP1APEX1 | |
| Cefixime SCHEMBL2063465 | 1.00 | APAF1 (1.00) | APAF1PSMD14MMP2TDP1APEX1 | |
| Cefixime SCHEMBL7718769 | 1.00 | APAF1 (1.00) | APAF1PSMD14MMP2TDP1APEX1 | |
| Cefixime SCHEMBL28463175 | 1.00 | APAF1 (1.00) | APAF1PSMD14MMP2TDP1APEX1 | |
| Cefixime SCHEMBL3553111 | 0.99 | TDP1 (1.00) | APAF1PSMD14MMP2TDP1APEX1 | |
| Cefixime SCHEMBL4812946 | 0.99 | TDP1 (1.00) | APAF1PSMD14MMP2TDP1APEX1 | |
| Cefixime SCHEMBL17131963 | 0.99 | TDP1 (1.00) | APAF1PSMD14MMP2TDP1APEX1 | |
| Cefixime SCHEMBL9483204 | 0.99 | TDP1 (1.00) | APAF1PSMD14MMP2TDP1APEX1 | |
| Cefixime SCHEMBL12374914 | 0.99 | TDP1 (1.00) | APAF1PSMD14MMP2TDP1APEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101220040-A | Preparation of cefixime cephalosporin and fine purification method | SI CHUAN DIRECTION PHOTOELECTR (CN) | 2008-07-16 | — | — | CN | disclosed |