Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 8/20 | 0.45 |
| ▸ | MAP3K11 | Q16584 | 5/20 | 0.44 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.42 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.42 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GAK | O14976 | 2/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL721146 | 0.77 | FLT3 (0.41) | FYNMAP3K11BRD4CHEK2GAK | |
| SCHEMBL19588442 | 0.76 | FYN (0.38) | FYNMAP3K11TGFBR1CHEK2 | |
| SCHEMBL20634204 | 0.76 | MAP3K11 (0.46) | FYNMAP3K11BRD4 | |
| SCHEMBL720602 | 0.72 | CHEK1 (0.59) | FYNMAP3K11BMPR1AACVRL1ACVR1 | |
| SCHEMBL8629038 | 0.70 | CYP11B2 (0.36) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL8137963 | 0.69 | HSD17B10 (0.41) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL26621580 | 0.69 | CYP11B2 (0.36) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL30661603 | 0.69 | CYP11B2 (0.36) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL27905885 | 0.68 | GAK (0.46) | FYNMAP3K11TGFBR1BRD4CHEK2 | |
| SCHEMBL11922155 | 0.67 | KDM4E (0.36) | BMPR1BBMPR1AACVRL1ACVR1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925319-B1 | MIXED LINEAGE KINASE INHIBITORS FOR HIV/AIDS THERAPIES | UNIV ROCHESTER (US) | 2019-01-09 | — | — | EP | disclosed |