Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 3/20 | 0.36 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.35 |
| ▸ | BMPR1B | O00238 | 6/20 | 0.35 |
| ▸ | BMPR1A | P36894 | 6/20 | 0.35 |
| ▸ | ACVRL1 | P37023 | 6/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 6/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.33 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | CASP6 | P55212 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.31 |
| ▸ | CCR1 | P32246 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL46315 | 0.84 | CYP11B2 (0.50) | CYP11B2BMPR1BBMPR1AACVRL1ACVR1 | |
| SCHEMBL26621580 | 0.81 | CYP11B2 (0.36) | CYP11B2TRIM24BMPR1BBMPR1AACVRL1 | |
| SCHEMBL30661603 | 0.81 | CYP11B2 (0.36) | CYP11B2TRIM24BMPR1BBMPR1AACVRL1 | |
| SCHEMBL8137963 | 0.81 | HSD17B10 (0.41) | CYP11B2TRIM24BMPR1BBMPR1AACVRL1 | |
| SCHEMBL27071821 | 0.78 | ACVRL1 (0.38) | CYP11B2BMPR1BBMPR1AACVRL1ACVR1 | |
| SCHEMBL11922155 | 0.78 | KDM4E (0.36) | CYP11B2TRIM24BMPR1BBMPR1AACVRL1 | |
| SCHEMBL8627202 | 0.77 | ALDH1A1 (0.34) | CYP11B2TRIM24BMPR1BBMPR1AACVRL1 | |
| SCHEMBL8630032 | 0.77 | MAPT (0.38) | CYP11B2BMPR1BBMPR1AACVRL1ACVR1 | |
| SCHEMBL18422666 | 0.77 | LMNA (0.35) | CYP11B2BMPR1BBMPR1AACVRL1ACVR1 | |
| SCHEMBL46312 | 0.75 | IDH1 (0.35) | IDH1KMT2AMEN1HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023212147-A1 | HETEROCYCLIC COMPOUNDS AS MODULATORS OF BCL6 AS LIGAND DIRECTED DEGRADERS | CELGENE CORPORATION (US) | 2023-11-02 | — | — | WO | disclosed |
| EP-3750880-B1 | PYRAZINE-2(1H)-KETONE COMPOUND ACTING AS FGFR INHIBITOR | ZHANGZHOU PIEN TZE HUANG PHARM (CN) | 2022-12-21 | — | — | EP | disclosed |
| WO-2022174253-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2022-08-18 | — | — | WO | disclosed |
| US-11286248-B2 | Pyrazine-2(1H)-ketone compound acting as FGFR inhibitor | ZHANGZHOU PIEN TZE HUANG PHARMACEUTICAL CO., LTD. (CN) | 2022-03-29 | — | — | US | disclosed |
| US-20210040070-A1 | PYRAZINE-2(1H)-KETONE COMPOUND ACTING AS FGFR INHIBITOR | ZHANGZHOU PIEN TZE HUANG PHARMACEUTICAL CO., LTD. (CN) | 2021-02-11 | — | — | US | disclosed |
| EP-3750880-A1 | PYRAZINE-2(1H)-KETONE COMPOUND ACTING AS FGFR INHIBITOR | Zhangzhou Pien Tze Huang Pharmaceutical Co., Ltd (CN) | 2020-12-16 | — | — | EP | disclosed |
| WO-2019154364-A1 | PYRAZINE-2(1H)-KETONE COMPOUND ACTING AS FGFR INHIBITOR | 南京明德新药研发有限公司 | 2019-08-15 | — | — | WO | disclosed |
| US-9120792-B2 | Fused heterocyclic compound | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2015-09-01 | — | — | US | disclosed |
| US-20150094329-A1 | FUSED HETEROCYCLIC COMPOUND | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2015-04-02 | — | — | US | disclosed |
| US-20110201629-A1 | CYCLOHEXYL AMIDE DERIVATIVES AS CRF RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2011-08-18 | — | — | US | disclosed |
| US-5767128-A | ANALGESICS | ADIR ET COMPAGNIE (FR) | 1998-06-16 | — | — | US | disclosed |
| US-5618819-A | ANALGESICS | ADIR ET COMPAGNIE (FR) | 1997-04-08 | — | — | US | disclosed |
| EP-0691339-A1 | Amine derivatives of 1,3-dihydro-2H-pyrrolo(2,3-b)pyridin-2-ones and oxazolo(4,5-b)pyridin-2(3H)-ones, their process of preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-01-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210040070-A1 | PYRAZINE-2(1H)-KETONE COMPOUND ACTING AS FGFR INHIBITOR | FGFR1, FGFR2, FGFR3 | CYP11B2 164/4885TRIM24 3555/4885BMPR1B 950/4885 |
| US-20110201629-A1 | CYCLOHEXYL AMIDE DERIVATIVES AS CRF RECEPTOR ANTAGONISTS | CRHR1, CRHR2, CRH | CYP11B2 838/4885TRIM24 3148/4885BMPR1B 1063/4885 |
| US-11286248-B2 | Pyrazine-2(1H)-ketone compound acting as FGFR inhibitor | FGFR1, FGFR2, FGFR3 | CYP11B2 164/4885TRIM24 3555/4885BMPR1B 950/4885 |
| US-20150094329-A1 | FUSED HETEROCYCLIC COMPOUND | CYC1, H1-0, H1-3 | CYP11B2 67/4885TRIM24 4476/4885BMPR1B 542/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.