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SCHEMBL20636106

SCHEMBL20636106

CC(C)c1cccc(C(C)C)c1NC(=O)NS(=O)(=O)C1CCN(CCC(C)c2cc(Cl)cc(C(C)C)c2NC(=O)NS(=O)(=O)C2CCN(C)C2=O)C1=O

nearest known ligand 0.43

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ NLRP3 Q96P20 4/20 0.43
▸ GSTO1 P78417 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22433090 0.86 NLRP3 (0.45) NLRP3GSTO1
SCHEMBL20635005 0.84 NLRP3 (0.39) NLRP3GSTO1
SCHEMBL22433089 0.84 NLRP3 (0.48) NLRP3
SCHEMBL20635002 0.83 NLRP3 (0.40) NLRP3GSTO1
SCHEMBL20636104 0.81 NLRP3 (0.39) NLRP3GSTO1
SCHEMBL22433092 0.81 NLRP3 (0.44) NLRP3GSTO1
SCHEMBL22433091 0.79 NLRP3 (0.46) NLRP3
SCHEMBL20636097 0.79 NLRP3 (0.41) NLRP3GSTO1
SCHEMBL20634986 0.79 NLRP3 (0.47) NLRP3GSTO1
SCHEMBL20634931 0.78 NLRP3 (0.44) NLRP3GSTO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019008025-A1 NOVEL SULFONAMIDE CARBOXAMIDE COMPOUNDS INFLAZOME LIMITED (IE) 2019-01-10 — — WO disclosed
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