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SCHEMBL20635005

SCHEMBL20635005

CC(C)c1cc(Cl)cc(C(C)CCC(C)c2cccc(C(C)C)c2NC(=O)NS(=O)(=O)C2CCCN(CC(F)(F)F)C2=O)c1NC(=O)NS(=O)(=O)C1CCCN(C)C1=O

nearest known ligand 0.39

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ NLRP3 Q96P20 5/20 0.39
▸ GSTO1 P78417 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20635000 0.88 NLRP3 (0.40) NLRP3GSTO1
SCHEMBL22433582 0.86 MEN1 (0.43) —
SCHEMBL20635002 0.86 NLRP3 (0.40) NLRP3GSTO1
SCHEMBL20636106 0.84 NLRP3 (0.43) NLRP3GSTO1
SCHEMBL20636097 0.83 NLRP3 (0.41) NLRP3GSTO1
SCHEMBL20634989 0.82 GSTO1 (0.39) NLRP3GSTO1
SCHEMBL22433092 0.82 NLRP3 (0.44) NLRP3GSTO1
SCHEMBL20636092 0.81 MEN1 (0.44) —
SCHEMBL20635003 0.81 PER2 (0.34) NLRP3GSTO1
SCHEMBL22433091 0.81 NLRP3 (0.46) NLRP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019008025-A1 NOVEL SULFONAMIDE CARBOXAMIDE COMPOUNDS INFLAZOME LIMITED (IE) 2019-01-10 — — WO disclosed
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