SCHEMBL206387

SCHEMBL206387

O=C(Cl)c1cccc([N+](=O)[O-])c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 1.00
TSHR P16473 4/20 1.00
CES2 O00748 1/20 0.72
CES1 P23141 1/20 0.72
TP53 P04637 1/20 0.70
KMT2A Q03164 5/20 0.60
MEN1 O00255 4/20 0.60
LMNA P02545 1/20 0.59
PRSS1 P07477 1/20 0.59
PRSS2 P07478 1/20 0.59
PRSS3 P35030 1/20 0.59
RXFP1 Q9HBX9 1/20 0.55
TDP1 Q9NUW8 1/20 0.55
ALOX15 P16050 1/20 0.55
MAPT P10636 4/20 0.54
POLB P06746 2/20 0.54
BLM P54132 1/20 0.54
HTT P42858 2/20 0.54
RAB9A P51151 1/20 0.54
CTDSP1 Q9GZU7 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30006288 1.00 ALDH1A1 (1.00) ALDH1A1TSHRCES2CES1TP53
SCHEMBL10868553 0.96 ALDH1A1 (0.93) ALDH1A1TSHRCES2CES1TP53
SCHEMBL8590575 0.95 ALDH1A1 (0.90) ALDH1A1TSHRCES2CES1TP53
Benzoyl Chloride SCHEMBL11355880 0.95 ALDH1A1 (0.90) ALDH1A1TSHRCES2CES1TP53
SCHEMBL6260279 0.87 ALDH1A1 (0.77) ALDH1A1TSHRCES2CES1TP53
SCHEMBL8107324 0.86 ALDH1A1 (0.74) ALDH1A1TSHRCES2CES1TP53
SCHEMBL2106897 0.85 KMT2A (0.76) ALDH1A1TSHRKMT2AMEN1MAPT
SCHEMBL181572 0.84 CES2 (0.78) ALDH1A1TSHRCES2CES1TP53
SCHEMBL2156825 0.84 CES1 (1.00) ALDH1A1TSHRCES2CES1TP53
SCHEMBL31374765 0.84 CES1 (1.00) ALDH1A1TSHRCES2CES1TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3447 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12528777-B2 Quinazolinones derivatives for treatment of non-alcoholic fatty liver disease, preparation and use thereof COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2026-01-20 US claimed
CN-116874839-B Preparation method of polyimide film with low thermal expansion coefficient for copper-clad plate 黄山金石木塑料科技有限公司 2025-04-18 CN claimed
CN-119798111-A Green synthesis method of N, N' - (carbonylbis (4, 1-phenylene)) bis (3-nitrobenzamide) 山东阳谷华泰化工股份有限公司 2025-04-11 CN claimed
CN-119661394-A Method for preparing 2, 2-bis (3-m-nitrobenzamide-4-hydroxyphenyl) hexafluoropropane by using microchannel reactor 山东阳谷华泰化工股份有限公司 2025-03-21 CN claimed
CN-119661392-A Method for preparing 2, 2-bis (3-m-nitrobenzamide-4-hydroxyphenyl) hexafluoropropane in environment-friendly manner 山东阳谷华泰化工股份有限公司 2025-03-21 CN claimed
CN-119661393-A Method for preparing N, N' - (carbonylbis (4, 1-phenylene)) bis (3-nitrobenzamide) through microchannel reaction 山东阳谷华泰化工股份有限公司 2025-03-21 CN claimed
CN-116178203-B Polyimide containing amide bond and benzonorbornane structure and preparation method thereof 南昌大学 2025-02-14 CN claimed
CN-118914412-A Method for detecting midbody and isomer impurity thereof 北京海步医药科技有限公司 2024-11-08 CN claimed
CN-118063934-B Modified TPEE composite material and preparation method thereof 江苏科奕莱新材料科技有限公司 2024-09-06 CN claimed
US-20240287008-A1 METHOD FOR THE SYNTHESIS OF 3-R-1,4,2-DIOXAZOL-5-ONES PANASONIC HOLDINGS CORPORATION (JP) 2024-08-29 US claimed
US-5068447-A Friedel-crafts preparation of aromatic ketones with an inoganic salt controlling agent RAYCHEM CORPORATION (US) 1991-11-26 US claimed
US-4952708-A REACTING SUBSTITUTED AROMATIC ACID HALIDES WITH SUBSTITUTED DI-OR POLYSILANES USING TRANSITION METAL COMPLEX AS CATALYST GENERAL ELECTRIC COMPANY (US) 1990-08-28 US claimed
EP-0363584-A2 Silylation method GENERAL ELECTRIC COMPANY (US) 1990-04-18 EP claimed
US-4918197-A CATALYTIC REACTION BETWEEN AROMATIC ACYLHALIDE AND HALOGENATED POLYSILANE GENERAL ELECTRIC COMPANY (US) 1990-04-17 US claimed
EP-0339455-A2 Process for preparing biaryl compounds GENERAL ELECTRIC COMPANY (US) 1989-11-02 EP claimed
US-4814508-A Friedel-crafts preparation of aromatic ketones RAYCHEM CORPORATION (US) 1989-03-21 US claimed
EP-0284873-A2 Silylation method GENERAL ELECTRIC COMPANY (US) 1988-10-05 EP claimed
US-4470930-A Preparation of nuclear chlorinated aromatic compounds OCCIDENTAL CHEMICAL CORPORATION (US) 1984-09-11 US claimed
US-4343871-A GROUP IA METAL ANODE AND CATHODE FORMED OF ORGANIC COMPOUND HAVINGPI-ELECTRON CONJUGATED SYSTEM NIPPON TELEGRAPH & TELEPHONE PUBLIC CORPORATION (JP) 1982-08-10 US claimed
US-4142853-A BENZOYLATION SHIKIBO LIMITED (JP) 1979-03-06 US claimed