Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 11/20 | 0.54 |
| ▸ | CDK19 | Q9BWU1 | 11/20 | 0.54 |
| ▸ | CCNC | P24863 | 7/20 | 0.53 |
| ▸ | SMO | Q99835 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | EED | O75530 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18758215 | 0.91 | CDK8 (0.50) | CDK8CDK19CCNCSMOLMNA | |
| SCHEMBL17113511 | 0.83 | CDK8 (0.52) | CDK8CDK19CCNCSMOLMNA | |
| SCHEMBL18747990 | 0.78 | CDK8 (0.59) | CDK8CDK19CCNCSMOLMNA | |
| SCHEMBL17129033 | 0.78 | CDK8 (0.60) | CDK8CDK19CCNCSMOLMNA | |
| SCHEMBL17113642 | 0.75 | CDK8 (0.62) | CDK8CDK19CCNCSMOLMNA | |
| SCHEMBL760272 | 0.74 | LMNA (0.49) | CDK8CDK19CCNCSMOLMNA | |
| SCHEMBL1096010 | 0.72 | LMNA (0.55) | CDK8CDK19CCNCSMOLMNA | |
| SCHEMBL17129049 | 0.72 | CDK8 (1.00) | CDK8CDK19CCNCHDAC1 | |
| SCHEMBL18747994 | 0.71 | CDK8 (1.00) | CDK8CDK19CCNC | |
| SCHEMBL6683284 | 0.71 | CYP2D6 (0.62) | CDK8CDK19CCNCSMOLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3122739-B1 | PYRIDYL PIPERIDINES | MERCK PATENT GMBH (DE) | 2019-01-16 | — | — | EP | disclosed |