Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | DRD1 | P21728 | 1/20 | 0.49 |
| ▸ | SMO | Q99835 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | EED | O75530 | 1/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 6/20 | 0.43 |
| ▸ | CDK19 | Q9BWU1 | 6/20 | 0.43 |
| ▸ | CCNC | P24863 | 4/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL737636 | 0.85 | LMNA (0.49) | LMNACHRM2ADRA2ACYP2D6TSHR | |
| SCHEMBL6683284 | 0.85 | CYP2D6 (0.62) | LMNACHRM2ADRA2ACYP2D6TSHR | |
| SCHEMBL736895 | 0.85 | HTR3E (0.48) | LMNACHRM2ADRA2ACYP2D6TSHR | |
| SCHEMBL761450 | 0.80 | LRRK2 (0.43) | MAPTKMT2AADRB1HTR7DRD2 | |
| SCHEMBL13211932 | 0.78 | GABRD (0.54) | LMNACHRM2ADRA2ACYP2D6TSHR | |
| SCHEMBL14817982 | 0.76 | ALDH1A1 (0.50) | LMNACHRM2ADRA2ACYP2D6TSHR | |
| SCHEMBL20644693 | 0.74 | CDK8 (0.54) | LMNACHRM2ADRA2ACYP2D6TSHR | |
| SCHEMBL737588 | 0.74 | HRH3 (0.49) | — | |
| SCHEMBL17543949 | 0.74 | ADRB1 (0.50) | TSHRMAPTKMT2AADRB1AKR1C3 | |
| SCHEMBL1096010 | 0.74 | LMNA (0.55) | LMNACHRM2ADRA2ACYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138206-B2 | Piperidine derivative | MSD. K.K. (JP) | 2012-03-20 | — | — | US | disclosed |
| US-20090137576-A1 | Novel Piperidine Derivative | MSD K.K. (JP) | 2009-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137576-A1 | Novel Piperidine Derivative | HRH4, HRH3, HRH1 | LMNA 4494/4885CHRM2 10/4885ADRA2A 208/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.