Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.40 |
| ▸ | MMP1 | P03956 | 2/20 | 0.39 |
| ▸ | MMP9 | P14780 | 2/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | STS | P08842 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | MMP7 | P09237 | 1/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.38 |
| ▸ | BACE1 | P56817 | 2/20 | 0.38 |
| ▸ | CTSD | P07339 | 1/20 | 0.38 |
| ▸ | CTSE | P14091 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | BMP1 | P13497 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20137495 | 0.75 | SMN1; SMN2 (0.49) | LMNAMAPTSMN1; SMN2ALDH1A1GPR119 | |
| SCHEMBL4634513 | 0.73 | JAK2 (0.50) | SMN1; SMN2GPR119STS | |
| SCHEMBL22911797 | 0.72 | LMNA (0.43) | LMNAMAPTSMN1; SMN2ALDH1A1GPR119 | |
| SCHEMBL18748005 | 0.72 | LMNA (0.45) | LMNAMAPTSMN1; SMN2ALDH1A1GPR119 | |
| SCHEMBL18669630 | 0.72 | STS (0.47) | LMNAMAPTSMN1; SMN2ALDH1A1GPR119 | |
| SCHEMBL17113489 | 0.72 | LMNA (0.44) | LMNAMAPTSMN1; SMN2ALDH1A1GPR119 | |
| SCHEMBL6159582 | 0.71 | LMNA (0.49) | LMNAMAPTSMN1; SMN2ALDH1A1GPR119 | |
| SCHEMBL23986656 | 0.71 | ALDH1A1 (0.66) | LMNAMAPTALDH1A1HTTMEN1 | |
| SCHEMBL24097945 | 0.70 | ALDH1A1 (0.50) | LMNAMAPTSMN1; SMN2ALDH1A1GPR119 | |
| SCHEMBL12493302 | 0.70 | MAPT (0.55) | LMNAMAPTSMN1; SMN2ALDH1A1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3122739-B1 | PYRIDYL PIPERIDINES | MERCK PATENT GMBH (DE) | 2019-01-16 | — | — | EP | disclosed |