Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | WDR5 | P61964 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | APEX1 | P27695 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19659321 | 0.83 | ALDH1A1 (0.33) | MAPK1SMN1; SMN2RIPK1HSD17B10ALDH1A1 | |
| SCHEMBL23256256 | 0.81 | HTT (0.35) | MAPK1SMN1; SMN2HSD17B10POLB | |
| SCHEMBL20645899 | 0.81 | RIPK1 (0.36) | SMN1; SMN2RIPK1 | |
| SCHEMBL20228866 | 0.81 | RIPK1 (0.44) | SMN1; SMN2RIPK1ALDH1A1 | |
| SCHEMBL20645939 | 0.81 | RIPK1 (0.44) | SMN1; SMN2RIPK1MAPTTP53HPGD | |
| SCHEMBL20645767 | 0.80 | RIPK1 (0.38) | SMN1; SMN2RIPK1 | |
| SCHEMBL20228736 | 0.80 | RIPK1 (0.35) | SMN1; SMN2RIPK1MAPTTP53HPGD | |
| SCHEMBL20646022 | 0.77 | RIPK1 (0.50) | RIPK1 | |
| SCHEMBL20645781 | 0.77 | RIPK1 (0.41) | SMN1; SMN2RIPK1 | |
| SCHEMBL20645803 | 0.77 | POLB (0.46) | MAPTTP53HPGDHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4397309-A2 | BICYCLIC KETONE COMPOUNDS AND METHODS OF USE THEREOF | F. Hoffmann-La Roche AG (CH) | 2024-07-10 | — | — | EP | disclosed |
| EP-3652178-B1 | BICYCLIC KETONE COMPOUNDS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2024-01-24 | — | — | EP | disclosed |
| WO-2019012063-A1 | BICYCLIC KETONE COMPOUNDS AND METHODS OF USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2019-01-17 | — | — | WO | disclosed |