Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 9/20 | 0.34 |
| ▸ | CDK9 | P50750 | 4/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.32 |
| ▸ | CDK2 | P24941 | 2/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.32 |
| ▸ | CDK7 | P50613 | 1/20 | 0.31 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.31 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15026289 | 0.89 | CDK2 (0.38) | PDE10ACRHR1CDK9CCNT1CDK2 | |
| SCHEMBL10280539 | 0.87 | PDE10A (0.38) | PDE10ACDK9CCNT1CDK2CHEK1 | |
| SCHEMBL7874289 | 0.87 | PDE10A (0.36) | PDE10ACRHR1CDK9CCNT1CDK2 | |
| SCHEMBL10280538 | 0.87 | PDE10A (0.38) | PDE10ACDK9CCNT1CDK2CHEK1 | |
| SCHEMBL28310 | 0.87 | PDE10A (0.37) | PDE10ACRHR1CDK9CCNT1CDK2 | |
| SCHEMBL7883324 | 0.86 | DGAT1 (0.37) | PDE10ACRHR1CDK9CCNT1CDK2 | |
| SCHEMBL1072955 | 0.86 | DGAT1 (0.37) | PDE10ACRHR1CDK9CCNT1CDK2 | |
| SCHEMBL22064 | 0.86 | PDE10A (0.34) | PDE10ACRHR1CDK9CDK2CHEK1 | |
| SCHEMBL20682 | 0.86 | PDE10A (0.34) | PDE10ACRHR1CDK9CDK2CHEK1 | |
| SCHEMBL15807254 | 0.85 | CDK9 (0.33) | PDE10ACRHR1CDK9CCNT1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012027236-A1 | NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | SCHERING CORPORATION (US) | 2012-03-01 | — | — | WO | disclosed |
| WO-2012027239-A1 | NOVEL PYRAZOLO[1,5-a]PYRROLO[3,2-e]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | SCHERING CORPORATION (US) | 2012-03-01 | — | — | WO | disclosed |