Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.37 |
| ▸ | NQO2 | P16083 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | PER2 | O15055 | 1/20 | 0.32 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8903181 | 0.89 | KDM4E (0.43) | KDM4EPIK3CDNQO2CNR1CNR2 | |
| SCHEMBL29954446 | 0.82 | KDM4E (0.46) | KDM4EPIK3CDNQO2CNR1CNR2 | |
| SCHEMBL4439323 | 0.81 | KDM4E (0.45) | KDM4EPIK3CDNQO2CNR1CNR2 | |
| SCHEMBL1712876 | 0.79 | — | — | |
| SCHEMBL6284243 | 0.74 | ALDH1A1 (0.41) | KDM4E | |
| SCHEMBL7625881 | 0.74 | — | — | |
| SCHEMBL16373804 | 0.74 | — | — | |
| SCHEMBL20105 | 0.74 | — | — | |
| SCHEMBL2037199 | 0.74 | — | — | |
| SCHEMBL510010 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120295329-A1 | CHEMICALLY MODIFIED MUTANT SERINE HYDROLASES SHOW IMPROVED CATALYTIC ACTIVITY AND CHIRAL SELECTIVITY | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2012-11-22 | — | — | US | claimed |
| US-20120156721-A1 | CHEMICALLY MODIFIED MUTANT SERINE HYDROLASES SHOW IMPROVED CATALYTIC ACTIVITY AND CHIRAL SELECTIVITY | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2012-06-21 | — | — | US | claimed |
| US-20090075329-A1 | CHEMICALLY MODIFIED MUTANT SERINE HYDROLASES SHOW IMPROVED CATALYTIC ACTIVITY AND CHIRAL SELECTIVITY | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2009-03-19 | — | — | US | claimed |
| US-20050282248-A1 | Chemically modified mutant serine hydrolases show improved catalytic activity and chiral selectivity | JONES JOHN B | 2005-12-22 | — | — | US | claimed |
| EP-1129180-A2 | CHEMICALLY MODIFIED MUTANT SERINE HYDROLASES | GENENCOR INTERNATIONAL, INC. (US) | 2001-09-05 | — | — | EP | claimed |
| WO-2000028007-A2 | CHEMICALLY MODIFIED MUTANT SERINE HYDROLASES | GENENCOR INTERNATIONAL, INC. (US) | 2000-05-18 | — | — | WO | claimed |
| US-8357524-B2 | Chemically modified mutant serine hydrolases show improved catalytic activity and chiral selectivity | DANISCO US INC. (US) | 2013-01-22 | — | — | US | disclosed |
| US-20120295329-A1 | CHEMICALLY MODIFIED MUTANT SERINE HYDROLASES SHOW IMPROVED CATALYTIC ACTIVITY AND CHIRAL SELECTIVITY | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2012-11-22 | — | — | US | disclosed |
| US-20120156721-A1 | CHEMICALLY MODIFIED MUTANT SERINE HYDROLASES SHOW IMPROVED CATALYTIC ACTIVITY AND CHIRAL SELECTIVITY | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2012-06-21 | — | — | US | disclosed |
| US-8148128-B2 | Chemically modified mutant serine hydrolases show improved catalytic activity and chiral selectivity | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2012-04-03 | — | — | US | disclosed |
| US-20090075329-A1 | CHEMICALLY MODIFIED MUTANT SERINE HYDROLASES SHOW IMPROVED CATALYTIC ACTIVITY AND CHIRAL SELECTIVITY | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2009-03-19 | — | — | US | disclosed |
| US-20050282248-A1 | Chemically modified mutant serine hydrolases show improved catalytic activity and chiral selectivity | JONES JOHN B | 2005-12-22 | — | — | US | disclosed |
| EP-1129180-A2 | CHEMICALLY MODIFIED MUTANT SERINE HYDROLASES | GENENCOR INTERNATIONAL, INC. (US) | 2001-09-05 | — | — | EP | disclosed |
| WO-2000028007-A2 | CHEMICALLY MODIFIED MUTANT SERINE HYDROLASES | GENENCOR INTERNATIONAL, INC. (US) | 2000-05-18 | — | — | WO | disclosed |