Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 4/20 | 0.47 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 4/20 | 0.39 |
| ▸ | CCKBR | P32239 | 1/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20652663 | 0.86 | ROCK2 (0.50) | ROCK2NPY5RKIF11ACHECCKBR | |
| SCHEMBL20652707 | 0.84 | ROCK2 (0.48) | ROCK2NPY5RKIF11ACHECCKBR | |
| SCHEMBL23418021 | 0.84 | ROCK2 (0.48) | ROCK2NPY5RKIF11ACHECCKBR | |
| SCHEMBL20652858 | 0.83 | ROCK2 (0.48) | ROCK2NPY5RKIF11ACHECCKBR | |
| SCHEMBL23391734 | 0.81 | TBXAS1 (0.52) | ROCK2NPY5RKIF11ACHETBXAS1 | |
| SCHEMBL31104422 | 0.81 | TBXAS1 (0.52) | ROCK2NPY5RKIF11ACHETBXAS1 | |
| SCHEMBL23418227 | 0.81 | ROCK2 (0.46) | ROCK2NPY5RKIF11ACHECCKBR | |
| SCHEMBL23418272 | 0.81 | ROCK2 (0.46) | ROCK2NPY5RKIF11ACHECCKBR | |
| SCHEMBL20652942 | 0.80 | KDM4E (0.50) | ROCK2NPY5RKIF11ACHETBXAS1 | |
| SCHEMBL27051267 | 0.80 | MAPT (0.44) | ROCK2NPY5RKIF11ACHETBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019014429-A1 | COMPOUNDS FOR TAU PROTEIN DEGRADATION | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2019-01-17 | — | — | WO | disclosed |