Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 4/20 | 0.39 |
| ▸ | CDK2 | P24941 | 4/20 | 0.39 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.39 |
| ▸ | CDK1 | P06493 | 2/20 | 0.39 |
| ▸ | CDK4 | P11802 | 2/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.39 |
| ▸ | CCND1 | P24385 | 2/20 | 0.39 |
| ▸ | CCND2 | P30279 | 2/20 | 0.39 |
| ▸ | CCND3 | P30281 | 2/20 | 0.39 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 10/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 4/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | ITK | Q08881 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2066815 | 0.88 | JAK3 (0.40) | CCNE1CDK2CCNE2CCNB2CDK1 | |
| SCHEMBL2065714 | 0.83 | JAK3 (0.39) | CCNE1CDK2CCNE2CCNB2CDK1 | |
| SCHEMBL3325437 | 0.80 | NTRK1 (0.42) | CCNE1CDK2CCNE2CCNB2CDK1 | |
| SCHEMBL2065120 | 0.79 | CCNB2 (0.41) | CCNE1CDK2CCNE2CCNB2CDK1 | |
| SCHEMBL10193671 | 0.78 | CCNB2 (0.42) | CCNE1CDK2CCNE2CCNB2CDK1 | |
| SCHEMBL3325439 | 0.78 | NTRK1 (0.37) | NTRK1KDRITK | |
| SCHEMBL14046742 | 0.77 | MYC (0.43) | CCNE1CDK2CCNE2CCNB2CDK1 | |
| SCHEMBL2065789 | 0.76 | CCNB2 (0.39) | CCNE1CDK2CCNE2CCNB2CDK1 | |
| SCHEMBL2066374 | 0.76 | KDM4E (0.39) | — | |
| SCHEMBL2065686 | 0.74 | FFAR2 (0.37) | CCNE1CDK2CCNE2CCNB2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8148400-B2 | Thiazolyl compounds useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-04-03 | — | — | US | disclosed |