Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 10/20 | 0.39 |
| ▸ | KDR | P35968 | 4/20 | 0.38 |
| ▸ | ITK | Q08881 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 4/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.36 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.36 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | CCND2 | P30279 | 1/20 | 0.36 |
| ▸ | CCND3 | P30281 | 1/20 | 0.36 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2065687 | 0.88 | CCNE1 (0.39) | JAK3NTRK1KDRITKCDK2 | |
| SCHEMBL2065714 | 0.86 | JAK3 (0.39) | JAK3NTRK1KDRITKCDK2 | |
| SCHEMBL3325437 | 0.82 | NTRK1 (0.42) | JAK3NTRK1KDRCDK2CCNE1 | |
| SCHEMBL3325439 | 0.82 | NTRK1 (0.37) | NTRK1KDRITK | |
| SCHEMBL2065120 | 0.81 | CCNB2 (0.41) | NTRK1KDRCDK2CCNE1CCNE2 | |
| SCHEMBL14046742 | 0.79 | MYC (0.43) | NTRK1KDRCDK2CCNE1CCNE2 | |
| SCHEMBL2065789 | 0.78 | CCNB2 (0.39) | JAK3NTRK1KDRCDK2CCNE1 | |
| SCHEMBL10193671 | 0.76 | CCNB2 (0.42) | NTRK1CDK2CCNE1CCNE2CCNB2 | |
| SCHEMBL3832224 | 0.74 | L3MBTL1 (0.46) | — | |
| SCHEMBL2065686 | 0.71 | FFAR2 (0.37) | NTRK1KDRCDK2CCNE1CCNE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8148400-B2 | Thiazolyl compounds useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-04-03 | — | — | US | disclosed |