Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HMGCR | P04035 | 3/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | TOP2A | P11388 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9283567 | 1.00 | ALDH1A1 (0.37) | ALDH1A1CYP3A4CYP2D6TSHRCYP2C19 | |
| SCHEMBL10024024 | 1.00 | ALDH1A1 (0.37) | ALDH1A1CYP3A4CYP2D6TSHRCYP2C19 | |
| SCHEMBL9268071 | 0.86 | CYP3A4 (0.34) | ALDH1A1CYP3A4CYP2D6TSHRCYP2C19 | |
| SCHEMBL2065729 | 0.83 | HMGCR (0.35) | HMGCRHDAC1HDAC2HDAC6 | |
| SCHEMBL24088518 | 0.81 | SLC12A2 (0.36) | ALDH1A1CYP3A4CYP2D6TSHRCYP2C19 | |
| SCHEMBL21855740 | 0.81 | SLC12A2 (0.36) | ALDH1A1CYP3A4CYP2D6TSHRCYP2C19 | |
| SCHEMBL21855532 | 0.81 | SLC12A2 (0.36) | ALDH1A1CYP3A4CYP2D6TSHRCYP2C19 | |
| SCHEMBL3386471 | 0.80 | ALDH1A1 (0.36) | ALDH1A1CYP3A4CYP2D6TSHRCYP2C19 | |
| SCHEMBL3386468 | 0.80 | ALDH1A1 (0.36) | ALDH1A1CYP3A4CYP2D6TSHRCYP2C19 | |
| SCHEMBL27228919 | 0.80 | ALDH1A1 (0.36) | ALDH1A1CYP3A4CYP2D6TSHRCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8148550-B2 | selected from fluvastatin, rosuvastatin, cerivastatin, glenvastatin or atorvastatin, by reduction or lactonization of chemical intermediate compounds, then hydrogenation, decyclization and deprotection of hydroxy groups | RATIOPHARM GMBH (DE) | 2012-04-03 | — | — | US | disclosed |
| US-20080249306-A1 | Method for the Production of Statins | RATIOPHARM GMBH (DE) | 2008-10-09 | — | — | US | disclosed |
| US-20070093660-A1 | Method for the production of statins | RATIOPHARM GMBH (DE) | 2007-04-26 | — | — | US | disclosed |
| US-5443970-A | SEPARATION OF ISOMERS IN A MIXTURE BY SELECTIVE REACTION | ZENECA LIMITED (GB) | 1995-08-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070093660-A1 | Method for the production of statins | HMGCR, CYP11A1, CYP51A1 | ALDH1A1 673/4885CYP3A4 98/4885CYP2D6 122/4885 |
| US-20080249306-A1 | Method for the Production of Statins | HMGCR, COASY, PCSK9 | ALDH1A1 862/4885CYP3A4 95/4885CYP2D6 346/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.