Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.97 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.97 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.63 |
| ▸ | MEN1 | O00255 | 4/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | GAA | P10253 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.54 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL624781 | 0.98 | TDP1 (1.00) | TDP1CYP3A4ALDH1A1MEN1KMT2A | |
| SCHEMBL31650393 | 0.84 | TDP1 (0.74) | TDP1CYP3A4ALDH1A1MEN1KMT2A | |
| SCHEMBL18273020 | 0.81 | CYP3A4 (0.69) | TDP1CYP3A4ALDH1A1MEN1KMT2A | |
| SCHEMBL3455462 | 0.80 | TDP1 (0.69) | TDP1CYP3A4ALDH1A1MEN1KMT2A | |
| SCHEMBL3072555 | 0.79 | ALDH1A1 (0.67) | TDP1CYP3A4ALDH1A1MEN1KMT2A | |
| SCHEMBL3123406 | 0.79 | ALDH1A1 (0.67) | TDP1CYP3A4ALDH1A1MEN1KMT2A | |
| SCHEMBL5730270 | 0.79 | ALDH1A1 (0.67) | TDP1CYP3A4ALDH1A1MEN1KMT2A | |
| SCHEMBL7530942 | 0.78 | TDP1 (0.62) | TDP1CYP3A4ALDH1A1MEN1KMT2A | |
| SCHEMBL2209697 | 0.77 | ALDH1A1 (0.65) | TDP1CYP3A4ALDH1A1MEN1KMT2A | |
| SCHEMBL2000543 | 0.77 | ALDH1A1 (1.00) | TDP1CYP3A4ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200270240-A1 | BENZOTHIAZOLE AND PYRIDOTHIAZOLE COMPOUNDS AS SUMO ACTIVATORS | ICAHN SCHOOL MED MOUNT SINAI (US) | 2020-08-27 | — | — | US | disclosed |
| EP-3654975-A1 | BENZOTHIAZOLE AND PYRIDOTHIAZOLE COMPOUNDS AS SUMO ACTIVATORS | Icahn School of Medicine at Mount Sinai (US) | 2020-05-27 | — | — | EP | disclosed |
| WO-2019018718-A1 | BENZOTHIAZOLE AND PYRIDOTHIAZOLE COMPOUNDS AS SUMO ACTIVATORS | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2019-01-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200270240-A1 | BENZOTHIAZOLE AND PYRIDOTHIAZOLE COMPOUNDS AS SUMO ACTIVATORS | SUMO2, ATP2A2, ATP2A1 | TDP1 3699/4885CYP3A4 1218/4885ALDH1A1 3082/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.