Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | BRD4 | O60885 | 2/20 | 0.58 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NR0B1 | P51843 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | XIAP | P98170 | 1/20 | 0.41 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29040367 | 0.81 | MEN1 (0.67) | SMN1; SMN2ALDH1A1HSD17B10BRD4BRPF1 | |
| SCHEMBL1422842 | 0.75 | SMN1; SMN2 (0.71) | SMN1; SMN2ALDH1A1HSD17B10BRD4BRPF1 | |
| SCHEMBL1119999 | 0.75 | SMN1; SMN2 (0.71) | SMN1; SMN2ALDH1A1HSD17B10BRD4BRPF1 | |
| SCHEMBL20660794 | 0.75 | LMNA (0.46) | BRD4MAPTLMNA | |
| SCHEMBL7539164 | 0.75 | SMN1; SMN2 (0.65) | SMN1; SMN2ALDH1A1HSD17B10BRD4BRPF1 | |
| SCHEMBL23846427 | 0.74 | SMN1; SMN2 (1.00) | SMN1; SMN2ALDH1A1HSD17B10BRD4BRPF1 | |
| SCHEMBL31060459 | 0.74 | SMN1; SMN2 (1.00) | SMN1; SMN2ALDH1A1HSD17B10BRD4BRPF1 | |
| SCHEMBL2414207 | 0.73 | MAOB (0.49) | KDM4EMEN1KMT2ATP53MAPT | |
| SCHEMBL15415871 | 0.71 | MAOB (0.49) | ALDH1A1RAB9AMAPTHPGD | |
| SCHEMBL20660930 | 0.70 | SMN1; SMN2 (0.68) | SMN1; SMN2ALDH1A1HSD17B10BRD4BRPF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3700934-A1 | COMPOUNDS AND USES THEREOF | Yumanity Therapeutics, Inc. (US) | 2020-09-02 | — | — | EP | disclosed |
| WO-2019209948-A9 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-01-02 | — | — | WO | disclosed |
| WO-2019018795-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2019-01-24 | — | — | WO | disclosed |