Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | MMP1 | P03956 | 2/20 | 0.39 |
| ▸ | MMP2 | P08253 | 2/20 | 0.39 |
| ▸ | MMP9 | P14780 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | USP5 | P45974 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.33 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19923569 | 0.86 | SMN1; SMN2 (0.40) | KMT2AMEN1MMP1MMP2MMP9 | |
| SCHEMBL2066251 | 0.77 | CALCRL (0.39) | KMT2AMEN1MMP1MMP2MMP9 | |
| SCHEMBL11518634 | 0.73 | CSNK2A2 (0.41) | KMT2AMEN1MMP1MMP2MMP9 | |
| SCHEMBL19923446 | 0.71 | SMN1; SMN2 (0.41) | KMT2AMEN1MMP1MMP2MMP9 | |
| SCHEMBL19923786 | 0.70 | MITF (0.43) | KMT2AMEN1SMN1; SMN2TDP1LMNA | |
| SCHEMBL6758459 | 0.67 | CALCRL (0.39) | KMT2AMEN1SLC1A2CALCRL | |
| SCHEMBL4393271 | 0.67 | CALCRL (0.39) | KMT2AMEN1SLC1A2CALCRL | |
| SCHEMBL6758463 | 0.67 | CALCRL (0.39) | KMT2AMEN1SLC1A2CALCRL | |
| SCHEMBL19923594 | 0.67 | ALDH1A1 (0.37) | KMT2AMEN1MMP1MMP2MMP9 | |
| SCHEMBL4383332 | 0.65 | GAA (0.42) | KMT2AGAACALCRL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8148390-B2 | Monocyclic anilide spirolactam CGRP receptor antagonists | Merck, Sharp & Dohme, Corp. (US) | 2012-04-03 | — | — | US | disclosed |