SCHEMBL2067129

SCHEMBL2067129

Nc1ccc2cc(Br)ccc2c1-c1c(N)ccc2cc(Br)ccc12

nearest known ligand 0.50

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.50
KDM4E B2RXH2 2/20 0.50
MEN1 O00255 2/20 0.50
KMT2A Q03164 2/20 0.50
ALDH1A1 P00352 1/20 0.50
BACE1 P56817 2/20 0.44
CYP2A6 P11509 1/20 0.43
ERN1 O75460 1/20 0.42
GLA P06280 1/20 0.39
PLAU P00749 2/20 0.39
PDPK1 O15530 2/20 0.38
JAK2 O60674 2/20 0.38
NCEH1 Q6PIU2 2/20 0.36
HTT P42858 1/20 0.35
POLB P06746 1/20 0.35
PABPC1 P11940 1/20 0.34
ACHE P22303 1/20 0.34
HRH4 Q9H3N8 1/20 0.34
IMPDH2 P12268 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30274387 1.00 MAPT (0.50) MAPTKDM4EMEN1KMT2AALDH1A1
SCHEMBL26205130 0.92 MEN1 (0.47) MAPTKDM4EMEN1KMT2AALDH1A1
SCHEMBL11212824 0.83 MAPT (0.50) MAPTKDM4EMEN1KMT2AALDH1A1
SCHEMBL30368680 0.83 KDM4E (0.50) MAPTKDM4EMEN1KMT2AALDH1A1
SCHEMBL6126980 0.83 KDM4E (0.50) MAPTKDM4EMEN1KMT2AALDH1A1
SCHEMBL28461369 0.82 ESR1 (0.45) MAPTKDM4EMEN1KMT2AALDH1A1
SCHEMBL29240308 0.79 MAPT (0.47) MAPTKDM4EMEN1KMT2AALDH1A1
SCHEMBL3171263 0.79 MAPT (0.47) MAPTKDM4EMEN1KMT2AALDH1A1
SCHEMBL31022943 0.79 IMPDH2 (0.47) MAPTKDM4EMEN1KMT2AALDH1A1
SCHEMBL3825050 0.79 IMPDH2 (0.47) MAPTKDM4EMEN1KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230213863-A1 COMPOUND, RESIST UNDERLAYER FILM COMPOSITION INCLUDING SAME, AND RESIST UNDERLAYER FILM DONGJIN SEMICHEM CO., LTD. (KR) 2023-07-06 US disclosed
US-20230213863-A1 COMPOUND, RESIST UNDERLAYER FILM COMPOSITION INCLUDING SAME, AND RESIST UNDERLAYER FILM DONGJIN SEMICHEM CO., LTD. (KR) 2023-07-06 US disclosed
CN-113214170-B Diphenylpyrazine compound, polymer, organic electronic device, and display panel 广东聚华印刷显示技术有限公司 2023-04-18 CN disclosed
CN-113214170-A Diphenylpyrazine compound, polymer, organic electronic device, and display panel 广东聚华印刷显示技术有限公司 2021-08-06 CN disclosed
US-7902207-B2 Process for production of amines TAKASAGO INTERNATIONAL CORPORATION (JP) 2011-03-08 US disclosed
US-20100298559-A1 OPTICALLY ACTIVE DINICKEL COMPLEX AND METHOD FOR PRODUCING OPTICALLY ACTIVE AMINE USING THE OPTICALLY ACTIVE DINICKEL COMPLEX AS CATALYST NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2010-11-25 US disclosed
US-20100298559-A1 OPTICALLY ACTIVE DINICKEL COMPLEX AND METHOD FOR PRODUCING OPTICALLY ACTIVE AMINE USING THE OPTICALLY ACTIVE DINICKEL COMPLEX AS CATALYST NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2010-11-25 US disclosed
US-20100298559-A1 OPTICALLY ACTIVE DINICKEL COMPLEX AND METHOD FOR PRODUCING OPTICALLY ACTIVE AMINE USING THE OPTICALLY ACTIVE DINICKEL COMPLEX AS CATALYST NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2010-11-25 US disclosed
EP-2233468-A1 OPTICALLY ACTIVE DINICKEL COMPLEX AND METHOD FOR PRODUCING OPTICALLY ACTIVE AMINE USING THE OPTICALLY ACTIVE DINICKEL COMPLEX AS CATALYST Nissan Chemical Industries, Ltd. (JP) 2010-09-29 EP disclosed
US-20070142639-A1 Process for production of amines TAKASAGO INTERNATIONAL CORPORATION (JP) 2007-06-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070142639-A1 Process for production of amines SMS, CCNT1, PEAK1 MAPT 1941/4885KDM4E 1975/4885MEN1 194/4885
US-20100298559-A1 OPTICALLY ACTIVE DINICKEL COMPLEX AND METHOD FOR PRODUCING OPTICALLY ACTIVE AMINE USING THE OPTICALLY ACTIVE DINICKEL COMPLEX AS CATALYST C5, C9, CCNE1 MAPT 3244/4885KDM4E 2758/4885MEN1 339/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.