SCHEMBL2067945

SCHEMBL2067945

COc1cn2ncccc2n1

nearest known ligand 0.44

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
PDE4A P27815 1/20 0.32
KDM4E B2RXH2 2/20 0.32
NPC1 O15118 1/20 0.32
PKM P14618 1/20 0.32
EPHX2 P34913 1/20 0.32
RAB9A P51151 1/20 0.32
ACVR2A P27037 3/20 0.31
TGFBR2 P37173 3/20 0.31
PDGFRB P09619 1/20 0.31
PDGFRA P16234 1/20 0.31
RBP4 P02753 1/20 0.30
TGFBR1 P36897 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2066827 0.80 PDE4A (0.38) PDE4AKDM4ENPC1PKMRAB9A
Hydrochloric Acid SCHEMBL30669826 0.74 ACVR2A (0.44) KDM4ENPC1PKMRAB9AACVR2A
SCHEMBL1744717 0.74 RBP4 (0.32) KDM4ENPC1RAB9ARBP4
SCHEMBL2066959 0.74 DYRK1A (0.47) PDE4AKDM4ERBP4TGFBR1
SCHEMBL18397085 0.73 DYRK1A (0.44) KDM4EACVR2ATGFBR2TGFBR1
SCHEMBL30224182 0.73 KDM4E (0.36) PDE4AKDM4ENPC1RAB9A
SCHEMBL9968611 0.73 PDE4A (0.33) PDE4ARBP4
Hydrochloric Acid SCHEMBL23290947 0.72 DYRK1A (0.46) PDE4AKDM4ERBP4TGFBR1
SCHEMBL15004639 0.72 DYRK1A (0.39) KDM4ENPC1RAB9ARBP4
SCHEMBL27694212 0.72 GAA (0.49) KDM4ENPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4540248-A2 MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF Children's Hospital Medical Center (US) 2025-04-23 EP disclosed
WO-2023245123-A2 MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF CHILDREN'S HOSPITAL MEDICAL CENTER (US) 2023-12-21 WO disclosed
US-8148524-B2 Process for producing sulfonyl chloride compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-04-03 US disclosed
EP-1932846-B1 METHOD FOR PRODUCING SULFONYL CHLORIDE COMPOUND SUMITOMO CHEMICAL CO (JP) 2010-10-27 EP disclosed
US-20090247748-A1 PROCESS FOR PRODUCING SULFONYL CHLORIDE COMPOUND SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-10-01 US disclosed
EP-1932846-A1 METHOD FOR PRODUCING SULFONYL CHLORIDE COMPOUND Sumitomo Chemical Company, Limited (JP) 2008-06-18 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090247748-A1 PROCESS FOR PRODUCING SULFONYL CHLORIDE COMPOUND SALL4, CLCN2, CLIC1 PDE4A 4317/4885KDM4E 3606/4885NPC1 2888/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.