Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20730399 | 0.80 | ESR1 (0.40) | HPGDTSHRLMNA | |
| SCHEMBL13045903 | 0.78 | HPGD (0.46) | HPGDTSHRLMNA | |
| SCHEMBL921991 | 0.74 | — | — | |
| SCHEMBL27863455 | 0.74 | APP (0.38) | TSHRLMNA | |
| SCHEMBL21918093 | 0.73 | HPGD (0.42) | HPGDTSHRLMNA | |
| SCHEMBL1206026 | 0.72 | HPGD (0.53) | HPGDTSHRLMNA | |
| SCHEMBL1206509 | 0.71 | HPGD (0.56) | HPGDTSHRLMNA | |
| SCHEMBL16591601 | 0.70 | SMN1; SMN2 (0.46) | HPGDTSHRLMNA | |
| SCHEMBL21917834 | 0.70 | GPR84 (0.35) | HPGDTSHRLMNA | |
| SCHEMBL13004470 | 0.69 | HPGD (0.55) | HPGDTSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11180474-B2 | Dimethoxyphenyl substituted indole compounds as TLR7, TLR8 or TLR9 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-11-23 | — | — | US | disclosed |
| US-10189818-B2 | 5-(5-(2-(3-aminopropdoxy)-6-methoxyphenyl)-1H-pyrazol-3-ylamino)pyrazine-2-carbonitfile (S)-lactate monohydrate | ELI LILLY AND COMPANY (US) | 2019-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10189818-B2 | 5-(5-(2-(3-aminopropdoxy)-6-methoxyphenyl)-1H-pyrazol-3-ylamino)pyrazine-2-carbonitfile (S)-lactate monohydrate | CHEK2, CHEK1, LDHA | HPGD 1422/4885TSHR 4758/4885LMNA 1380/4885 |
| US-11180474-B2 | Dimethoxyphenyl substituted indole compounds as TLR7, TLR8 or TLR9 inhibitors | TLR9, TLR7, TLR8 | HPGD 4348/4885TSHR 628/4885LMNA 2725/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.