Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCLK1 | O15075 | 5/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 7/20 | 0.42 |
| ▸ | MAPK7 | Q13164 | 6/20 | 0.42 |
| ▸ | EGFR | P00533 | 3/20 | 0.42 |
| ▸ | AURKA | O14965 | 4/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.42 |
| ▸ | PIK3C2G | O75747 | 3/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.42 |
| ▸ | CDK7 | P50613 | 3/20 | 0.42 |
| ▸ | CCNH | P51946 | 3/20 | 0.42 |
| ▸ | CCNK | O75909 | 3/20 | 0.42 |
| ▸ | CDK12 | Q9NYV4 | 3/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.42 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16065777 | 0.86 | DCLK1 (0.59) | DCLK1LRRK2MAPK7EGFRAURKA | |
| SCHEMBL16065773 | 0.81 | ITK (0.59) | DCLK1LRRK2MAPK7EGFRAURKA | |
| SCHEMBL17854805 | 0.79 | MAPK7 (0.53) | DCLK1LRRK2MAPK7AURKAAURKB | |
| SCHEMBL17469559 | 0.78 | AURKA (0.45) | LRRK2EGFRAURKAAURKBPIK3CD | |
| SCHEMBL17469564 | 0.75 | MAPK7 (0.50) | LRRK2MAPK7AURKAAURKBPIK3CD | |
| SCHEMBL17469565 | 0.74 | EGFR (0.43) | LRRK2EGFRAURKAAURKBPIK3CD | |
| SCHEMBL21143422 | 0.74 | PIK3CG (0.64) | DCLK1LRRK2MAPK7AURKAAURKB | |
| SCHEMBL13389249 | 0.66 | EGFR (0.55) | EGFRCDK7CCNHMNAT1JAK3 | |
| SCHEMBL17469527 | 0.66 | CCNK (0.46) | CDK7CCNHCCNKCDK12CCNA2 | |
| SCHEMBL16974436 | 0.66 | MAPK7 (0.53) | DCLK1LRRK2MAPK7NUAK1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10189861-B2 | Pyrimido-diazepinone compounds and methods of treating disorders | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2019-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10189861-B2 | Pyrimido-diazepinone compounds and methods of treating disorders | BRSK2, GRK3, BRSK1 | DCLK1 483/4885LRRK2 324/4885MAPK7 292/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.