Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 6/20 | 0.64 |
| ▸ | DCLK1 | O15075 | 6/20 | 0.64 |
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.64 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.64 |
| ▸ | PIK3C2G | O75747 | 5/20 | 0.64 |
| ▸ | AURKA | O14965 | 5/20 | 0.64 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.64 |
| ▸ | MAPK7 | Q13164 | 5/20 | 0.64 |
| ▸ | BRD4 | O60885 | 2/20 | 0.56 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 4/20 | 0.46 |
| ▸ | CA2 | P00918 | 4/20 | 0.46 |
| ▸ | CA9 | Q16790 | 3/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | STK4 | Q13043 | 2/20 | 0.43 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17854805 | 0.87 | MAPK7 (0.53) | PIK3CGDCLK1LRRK2PIK3CDPIK3C2G | |
| SCHEMBL10098763 | 0.78 | PIK3CG (1.00) | PIK3CGDCLK1LRRK2PIK3CDPIK3C2G | |
| SCHEMBL20682528 | 0.74 | DCLK1 (0.43) | PIK3CGDCLK1LRRK2PIK3CDPIK3C2G | |
| SCHEMBL10098754 | 0.73 | PIK3CG (1.00) | PIK3CGDCLK1LRRK2PIK3CDPIK3C2G | |
| SCHEMBL10098766 | 0.72 | DCLK1 (0.58) | PIK3CGDCLK1LRRK2PIK3CDPIK3C2G | |
| SCHEMBL17465864 | 0.72 | PIK3CG (1.00) | PIK3CGDCLK1LRRK2PIK3CDPIK3C2G | |
| SCHEMBL16973746 | 0.72 | BRD4 (1.00) | PIK3CGDCLK1LRRK2PIK3CDPIK3C2G | |
| SCHEMBL17721092 | 0.71 | MAPK7 (0.57) | PIK3CGDCLK1LRRK2PIK3CDPIK3C2G | |
| SCHEMBL10098762 | 0.70 | LRRK2 (0.66) | PIK3CGDCLK1LRRK2PIK3CDPIK3C2G | |
| SCHEMBL10098691 | 0.70 | MAPK7 (0.56) | PIK3CGDCLK1LRRK2PIK3CDPIK3C2G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190192532-A1 | COMBINATION THERAPY OF BROMODOMAIN INHIBITORS AND CHECKPOINT BLOCKADE | PETER MACCALLUM CANCER INSTITUTE (AU) | 2019-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190192532-A1 | COMBINATION THERAPY OF BROMODOMAIN INHIBITORS AND CHECKPOINT BLOCKADE | BRD4, BRD3, BRPF3 | PIK3CG 3736/4885DCLK1 1875/4885LRRK2 1955/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.