⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2068322 | 0.90 | PDE10A (0.31) | — | |
| SCHEMBL25308587 | 0.81 | CLK2 (0.36) | — | |
| SCHEMBL2068403 | 0.77 | KDM4E (0.40) | — | |
| SCHEMBL2067363 | 0.77 | HTR3E (0.37) | — | |
| SCHEMBL1819991 | 0.72 | KMT2A (0.46) | — | |
| SCHEMBL22529934 | 0.72 | HTR3E (0.47) | — | |
| SCHEMBL2068134 | 0.72 | PIM1 (0.33) | — | |
| SCHEMBL2069492 | 0.69 | METAP2 (0.39) | — | |
| SCHEMBL2068582 | 0.67 | MAP4K4 (0.43) | — | |
| SCHEMBL2068155 | 0.67 | PIM1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438063-A1 | 1H-IMIDAZO[4,5-C]QUINOLINONE COMPOUNDS, USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Novartis AG (CH) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010139747-A1 | 1H-IMIDAZO[4, 5-c]QUINOLINONE COMPOUNDS, USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2010-12-09 | — | — | WO | disclosed |
| US-20100311714-A1 | 1H-IMIDAZO[4,5-c]QUINOLINONE COMPOUNDS | NOVARTIS AG (CH) | 2010-12-09 | — | — | US | disclosed |