Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.41 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | LTK | P29376 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | CDK7 | P50613 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | PLK1 | P53350 | 2/20 | 0.35 |
| ▸ | GRM5 | P41594 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1774897 | 0.86 | GAA (0.42) | MAPK14NR4A2HCAR3CSF1RMAPK8 | |
| SCHEMBL21550282 | 0.85 | ESR1 (0.35) | MAPK14NR4A2ESR1PLK1GRM5 | |
| SCHEMBL5756104 | 0.83 | GRM5 (0.36) | MAPK14ESR1GRM5 | |
| SCHEMBL20911283 | 0.81 | NR4A2 (0.34) | MAPK14NR4A2ESR1PLK1GRM5 | |
| SCHEMBL19402115 | 0.81 | NR4A2 (0.34) | MAPK14NR4A2ESR1PLK1GRM5 | |
| SCHEMBL11306797 | 0.80 | CCR4 (0.34) | CLK4ESR1GRM5 | |
| SCHEMBL20612065 | 0.80 | HCAR3 (0.43) | MAPK14HCAR3ESR1 | |
| SCHEMBL28277650 | 0.80 | HCAR3 (0.43) | MAPK14HCAR3ESR1 | |
| SCHEMBL20991790 | 0.80 | CFD (0.33) | NR4A2ESR1PLK1GRM5 | |
| SCHEMBL19402117 | 0.80 | MAPK9 (0.34) | NR4A2MAPK9ESR1PLK1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3434674-A1 | COMPOUND HAVING MUTANT IDH INHIBITORY ACTIVITY, PREPARATION METHOD AND USE THEREOF | Shanghai Haihe Pharmaceutical Co., Ltd. (CN) | 2019-01-30 | — | — | EP | disclosed |