Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ITK | Q08881 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15204446 | 0.92 | HSD11B1 (0.40) | HSD11B1ALDH1A1LMNAGAAMAPT | |
| SCHEMBL208606 | 0.90 | MMP13 (0.44) | HSD11B1ALDH1A1LMNASTAT3MAPK1 | |
| SCHEMBL209754 | 0.89 | HSD11B1 (0.45) | HSD11B1ALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL3548661 | 0.87 | HSD11B1 (0.51) | HSD11B1ALDH1A1GAAMAPTKDM4E | |
| Hydrochloric Acid SCHEMBL3879425 | 0.86 | HSD11B1 (0.50) | HSD11B1ALDH1A1GAAMAPTKDM4E | |
| SCHEMBL211427 | 0.86 | HSD11B1 (0.44) | HSD11B1ALDH1A1MAPK1USP2RAB9A | |
| SCHEMBL2722387 | 0.86 | CNR2 (0.46) | HSD11B1ALDH1A1MAPK1USP2KDM4E | |
| SCHEMBL209503 | 0.85 | HSD11B1 (0.43) | HSD11B1ALDH1A1LMNARAB9A | |
| SCHEMBL209985 | 0.85 | CNR2 (0.45) | HSD11B1ALDH1A1MAPK1USP2KDM4E | |
| SCHEMBL210958 | 0.85 | HRH3 (0.44) | HSD11B1ALDH1A1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088776-B2 | Biphenyl amide lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 | ELI LILLY AND COMPANY (US) | 2012-01-03 | — | — | US | claimed |
| US-8088776-B2 | Biphenyl amide lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 | ELI LILLY AND COMPANY (US) | 2012-01-03 | — | — | US | disclosed |