Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 6/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20686163 | 0.90 | MAP4K1 (0.34) | MAP4K1 | |
| SCHEMBL20686266 | 0.83 | MAP4K1 (0.36) | MAP4K1GAA | |
| SCHEMBL18549334 | 0.82 | ALDH1A1 (0.40) | MAP4K1GAA | |
| SCHEMBL20686203 | 0.81 | MAP4K1 (0.32) | MAP4K1 | |
| SCHEMBL20686145 | 0.80 | ALDH1A1 (0.38) | GAA | |
| SCHEMBL20686176 | 0.80 | MAP4K1 (0.32) | MAP4K1 | |
| SCHEMBL20686182 | 0.79 | MAP4K1 (0.31) | MAP4K1 | |
| SCHEMBL17275714 | 0.78 | RARB (0.38) | MAP4K1GAA | |
| SCHEMBL15577333 | 0.78 | HTT (0.44) | MAP4K1GAA | |
| SCHEMBL17275673 | 0.77 | SMN1; SMN2 (0.41) | MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3145923-B1 | INDOLIN-2-ONE AND 1,3-DIHYDRO-PYRROLO[3,2-C]PYRIDIN-2-ONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2019-01-30 | — | — | EP | disclosed |