Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.53 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.53 |
| ▸ | HRH1 | P35367 | 2/20 | 0.52 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | CHUK | O15111 | 1/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | PRKX | P51817 | 1/20 | 0.43 |
| ▸ | PRKG2 | Q13237 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18620969 | 0.89 | HRH1 (0.66) | CHRNB2CHRNA4HRH1PRKCZROCK1 | |
| SCHEMBL3133920 | 0.83 | PRKCZ (0.56) | CHRNB2CHRNA4HRH1PRKCZROCK1 | |
| SCHEMBL4067092 | 0.83 | PRKCZ (0.56) | CHRNB2CHRNA4HRH1PRKCZROCK1 | |
| SCHEMBL7000861 | 0.83 | PRKCZ (0.56) | CHRNB2CHRNA4HRH1PRKCZROCK1 | |
| SCHEMBL305532 | 0.81 | CHRNB2 (0.53) | CHRNB2CHRNA4HRH1PRKCZROCK1 | |
| SCHEMBL18295396 | 0.81 | HTR2C (0.59) | CHRNB2CHRNA4HRH1PRKCZROCK1 | |
| SCHEMBL2344178 | 0.81 | HTR2C (0.66) | CHRNB2CHRNA4HRH1PRKCZHTR2C | |
| SCHEMBL22953684 | 0.81 | HTR2C (0.59) | CHRNB2CHRNA4HRH1PRKCZROCK1 | |
| SCHEMBL22953095 | 0.81 | HTR2C (0.59) | CHRNB2CHRNA4HRH1PRKCZROCK1 | |
| SCHEMBL4125994 | 0.81 | HTR2C (0.59) | CHRNB2CHRNA4HRH1PRKCZROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4006017-A1 | SGLT2/DPP4 INHIBITOR AND APPLICATION THEREOF | Medshine Discovery Inc. (CN) | 2022-06-01 | — | — | EP | disclosed |
| EP-3524600-B1 | PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF NOVEL SUBSTITUTED 6,7-DIHYDRO-5H-BENZO[7]ANNULENE COMPOUNDS | SANOFI SA (FR) | 2021-11-17 | — | — | EP | disclosed |
| EP-3416962-B1 | 6,7-DIHYDRO-5H-BENZO[7]ANNULENE DERIVATIVES AS ESTROGEN RECEPTOR MODULATORS | SANOFI SA (FR) | 2021-05-05 | — | — | EP | disclosed |
| EP-3524600-A1 | PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF NOVEL SUBSTITUTED 6,7-DIHYDRO-5H-BENZO[7]ANNULENE COMPOUNDS | Sanofi (FR) | 2019-08-14 | — | — | EP | disclosed |
| EP-3434272-A1 | COMBINATION COMPRISING PALBOCICLIB AND 6-(2,4-DICHLOROPHENYL)-5-[4-[(3S)-1-(3-FLUOROPROPYL)PYRROLIDIN-3-YL]OXYPHENYL]-8,9-DIHYDRO-7H-BENZO[7]ANNULENE-2-CARBOXYLIC ACID | SANOFI (FR) | 2019-01-30 | — | — | EP | disclosed |