Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 9/20 | 0.71 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.53 |
| ▸ | BRAF | P15056 | 5/20 | 0.49 |
| ▸ | FYN | P06241 | 3/20 | 0.49 |
| ▸ | SRC | P12931 | 3/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.49 |
| ▸ | VCP | P55072 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | RAF1 | P04049 | 4/20 | 0.48 |
| ▸ | USP2 | O75604 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17047488 | 0.83 | PIK3CG (1.00) | PIK3CGPIK3CABRAFFYNSRC | |
| SCHEMBL15051337 | 0.70 | BRAF (0.84) | PIK3CGPIK3CABRAFEGFRRAF1 | |
| SCHEMBL4357423 | 0.69 | PIK3CG (0.53) | PIK3CGRAF1USP2LMNACYP1A2 | |
| SCHEMBL17047521 | 0.69 | PIK3CG (1.00) | PIK3CGPIK3CABRAFPIK3CDPIK3CB | |
| SCHEMBL17047554 | 0.69 | PIK3CG (1.00) | PIK3CGPIK3CABRAFPIK3CDPIK3CB | |
| SCHEMBL12630756 | 0.68 | ALDH1A1 (0.50) | LMNAALDH1A1 | |
| SCHEMBL18382198 | 0.68 | PIK3CG (0.81) | PIK3CGPIK3CABRAFPIK3CDPIK3CB | |
| SCHEMBL17047493 | 0.68 | PIK3CG (1.00) | PIK3CGPIK3CABRAFPIK3CDPIK3CB | |
| SCHEMBL15051632 | 0.67 | BRAF (0.73) | PIK3CGPIK3CABRAFFYNSRC | |
| SCHEMBL17047550 | 0.67 | PIK3CG (1.00) | PIK3CGPIK3CABRAFPIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3110801-B1 | 6-ARYL-4-PHENYLAMINO-QUINAZOLINE ANALOGS AS PHOSPHOINOSITIDE-3-KINASE INHIBITORS | COUNCIL SCIENT IND RES (IN) | 2019-01-30 | — | — | EP | disclosed |