Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 4/20 | 0.36 |
| ▸ | KIF18A | Q8NI77 | 8/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | CLK2 | P49760 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | STK3 | Q13188 | 1/20 | 0.33 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20688222 | 1.00 | SOS1 (0.39) | SOS1TYK2KIF18AALDH1A1ELOVL1 | |
| SCHEMBL20688212 | 0.87 | SOS1 (0.37) | SOS1TYK2KIF18AELOVL1ACACB | |
| SCHEMBL20696784 | 0.87 | SOS1 (0.42) | SOS1TYK2KIF18AELOVL1ACACB | |
| SCHEMBL21285288 | 0.87 | SOS1 (0.37) | SOS1TYK2KIF18AELOVL1ACACB | |
| SCHEMBL21245952 | 0.87 | SOS1 (0.42) | SOS1TYK2KIF18AELOVL1ACACB | |
| SCHEMBL21245951 | 0.87 | SOS1 (0.42) | SOS1TYK2KIF18AELOVL1ACACB | |
| SCHEMBL21227382 | 0.82 | TYK2 (0.46) | TYK2KIF18AACACBSYKPIK3CA | |
| SCHEMBL20689076 | 0.81 | GRIN2D (0.40) | SOS1KIF18AELOVL1PIK3CA | |
| SCHEMBL20689481 | 0.77 | POLB (0.36) | SOS1ALDH1A1ELOVL1 | |
| SCHEMBL13073621 | 0.76 | ALDH1A1 (0.49) | KIF18AALDH1A1PIK3CACLK2GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020154474-A1 | TYK2 INHIBITORS AND USES THEREOF | NIMBUS LAKSHMI, INC. (US) | 2020-07-30 | — | — | WO | disclosed |
| WO-2019023468-A1 | TYK2 INHIBITORS AND USES THEREOF | NIMBUS LAKSHMI, INC. (US) | 2019-01-31 | — | — | WO | disclosed |