Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 4/20 | 0.46 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | KIF18A | Q8NI77 | 6/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.32 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | NCF1 | P14598 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20697004 | 0.85 | TYK2 (0.41) | TYK2ACACBFFAR1PDCD1LG2CD274 | |
| SCHEMBL20688189 | 0.82 | SOS1 (0.39) | TYK2ACACBKIF18ASYKPIK3CA | |
| SCHEMBL20688222 | 0.82 | SOS1 (0.39) | TYK2ACACBKIF18ASYKPIK3CA | |
| SCHEMBL12075897 | 0.81 | TYK2 (0.44) | TYK2KIF18A | |
| SCHEMBL20688223 | 0.81 | TYK2 (0.51) | TYK2ACACBKIF18AKCNH2SLC6A2 | |
| SCHEMBL12958833 | 0.80 | HTR3E (0.50) | TYK2KCNH2 | |
| SCHEMBL12654062 | 0.77 | GRIN2D (0.44) | TYK2FFAR1PDCD1LG2CD274SLC6A2 | |
| SCHEMBL1812392 | 0.77 | TYK2 (0.42) | TYK2KIF18A | |
| SCHEMBL15999338 | 0.77 | ACACB (0.36) | TYK2ACACBFFAR1PDCD1LG2CD274 | |
| SCHEMBL13073621 | 0.75 | ALDH1A1 (0.49) | KIF18APIM1PIM3PIM2PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190241575-A1 | TYK2 INHIBITORS AND USES THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2019-08-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190241575-A1 | TYK2 INHIBITORS AND USES THEREOF | TYK2, JAK2, JAK1 | TYK2 1/4885ACACB 2158/4885FFAR1 4510/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.