Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 3/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22273180 | 0.89 | HTR6 (0.45) | HTR6TYK2CNR2KDM4EALDH1A1 | |
| SCHEMBL21227429 | 0.83 | HTR6 (0.49) | HTR6SIGMAR1TYK2CNR2HRH1 | |
| SCHEMBL20688030 | 0.77 | CNR2 (0.51) | TYK2CNR2ALDH1A1MAPTTRPM5 | |
| SCHEMBL20688049 | 0.75 | GSK3B (0.56) | CNR2TRPM5CNR1 | |
| SCHEMBL21258557 | 0.73 | CNR2 (0.54) | HTR6TYK2CNR2KDM4EALDH1A1 | |
| SCHEMBL26581577 | 0.73 | ICMT (0.41) | HTR6CNR2HRH3CNR1 | |
| SCHEMBL13437585 | 0.72 | HDAC3 (0.46) | HTR6CNR2KDM4ELMNAL3MBTL1 | |
| SCHEMBL13437568 | 0.72 | CNR1 (0.40) | HTR6CNR2TRPM5CNR1 | |
| SCHEMBL21245970 | 0.72 | HTR6 (0.42) | HTR6TYK2CNR2GAAMAPT | |
| SCHEMBL13437554 | 0.71 | SMN1; SMN2 (0.50) | HTR6CNR2ALDH1A1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020154474-A1 | TYK2 INHIBITORS AND USES THEREOF | NIMBUS LAKSHMI, INC. (US) | 2020-07-30 | — | — | WO | disclosed |
| WO-2019023468-A1 | TYK2 INHIBITORS AND USES THEREOF | NIMBUS LAKSHMI, INC. (US) | 2019-01-31 | — | — | WO | disclosed |