Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADCY5 | O95622 | 6/20 | 0.35 |
| ▸ | TYMP | P19971 | 1/20 | 0.34 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.31 |
| ▸ | PI4KA | P42356 | 1/20 | 0.31 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.31 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.31 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20691937 | 0.81 | P2RY1 (0.36) | ADCY5TYMPP2RY1DGAT1 | |
| SCHEMBL20691939 | 0.81 | P2RY1 (0.40) | ADCY5P2RY1DGAT1 | |
| SCHEMBL20692131 | 0.73 | SLC29A1 (0.35) | TYMP | |
| SCHEMBL9471687 | 0.73 | ADCY5 (0.44) | ADCY5TYMPP2RY1ADORA2AADORA3 | |
| SCHEMBL21637026 | 0.70 | BCHE (0.46) | P2RY1ADORA2AADORA3ADORA1ADORA2B | |
| SCHEMBL9685305 | 0.70 | ADCY5 (0.48) | ADCY5ADORA2AADORA3ADORA1ADORA2B | |
| SCHEMBL9469908 | 0.69 | ADORA2A (0.46) | TYMPADORA2AADORA3ADORA1ADORA2B | |
| SCHEMBL10475247 | 0.69 | ADCY5 (0.55) | ADCY5ADORA2AADORA3ADORA1ADORA2B | |
| SCHEMBL9685291 | 0.68 | ADCY5 (0.48) | ADCY5ADORA2AADORA3ADORA1ADORA2B | |
| SCHEMBL20927097 | 0.68 | ALDH1A1 (0.37) | ADORA3ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3658565-B1 | CYCLIC DINUCLEOTIDES AS ANTICANCER AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2022-11-09 | — | — | EP | disclosed |
| EP-3752516-B1 | CYCLIC DINUCLEOTIDES AS ANTICANCER AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2022-02-23 | — | — | EP | disclosed |
| WO-2019023459-A1 | CYCLIC DINUCLEOTIDES AS ANTICANCER AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-01-31 | — | — | WO | disclosed |