Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 9/20 | 0.36 |
| ▸ | CA1 | P00915 | 8/20 | 0.36 |
| ▸ | CA12 | O43570 | 6/20 | 0.36 |
| ▸ | CA9 | Q16790 | 5/20 | 0.36 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.35 |
| ▸ | TGM2 | P21980 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25033764 | 0.88 | NLRP3 (0.40) | CA2CA1CA12CA9NLRP3 | |
| SCHEMBL20692355 | 0.87 | NLRP3 (0.35) | CA2CA1CA12CA9NLRP3 | |
| SCHEMBL26009908 | 0.87 | NLRP3 (0.35) | CA2CA1CA12CA9NLRP3 | |
| SCHEMBL23481741 | 0.87 | NLRP3 (0.35) | CA2CA1CA12CA9NLRP3 | |
| SCHEMBL30244043 | 0.85 | PTGDR2 (0.38) | CA2CA1CA12CA9NLRP3 | |
| SCHEMBL30243773 | 0.85 | PTGDR2 (0.38) | CA2CA1CA12CA9NLRP3 | |
| SCHEMBL20692406 | 0.85 | PTGDR2 (0.38) | CA2CA1CA12CA9NLRP3 | |
| SCHEMBL22012199 | 0.82 | NLRP3 (0.33) | CA2CA1CA12CA9NLRP3 | |
| SCHEMBL20692391 | 0.81 | NLRP3 (0.41) | CA2CA1CA12CA9NLRP3 | |
| SCHEMBL20692385 | 0.81 | NLRP3 (0.41) | CA2CA1CA12CA9NLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020102576-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |
| WO-2019023147-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | IFM Tre, Inc. (US) | 2019-01-31 | — | — | WO | disclosed |