Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 3/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.32 |
| ▸ | CA12 | O43570 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | CA9 | Q16790 | 2/20 | 0.32 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.32 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.32 |
| ▸ | TGM2 | P21980 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25033764 | 0.84 | NLRP3 (0.40) | NLRP3HSP90AA1CA12CA1CA2 | |
| SCHEMBL20692355 | 0.83 | NLRP3 (0.35) | NLRP3HSP90AA1CA12CA1CA2 | |
| SCHEMBL26009908 | 0.83 | NLRP3 (0.35) | NLRP3HSP90AA1CA12CA1CA2 | |
| SCHEMBL23481741 | 0.83 | NLRP3 (0.35) | NLRP3HSP90AA1CA12CA1CA2 | |
| SCHEMBL20692181 | 0.82 | CA2 (0.36) | NLRP3HSP90AA1CA12CA1CA2 | |
| SCHEMBL20692406 | 0.81 | PTGDR2 (0.38) | NLRP3HSP90AA1CA12CA1CA2 | |
| SCHEMBL30244043 | 0.81 | PTGDR2 (0.38) | NLRP3HSP90AA1CA12CA1CA2 | |
| SCHEMBL30243773 | 0.81 | PTGDR2 (0.38) | NLRP3HSP90AA1CA12CA1CA2 | |
| SCHEMBL22013424 | 0.76 | NLRP3 (0.35) | NLRP3 | |
| SCHEMBL22012200 | 0.75 | CA2 (0.37) | NLRP3CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020102576-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |