Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 4/20 | 0.53 |
| ▸ | MAOB | P27338 | 4/20 | 0.53 |
| ▸ | DRD1 | P21728 | 10/20 | 0.49 |
| ▸ | DRD5 | P21918 | 9/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 7/20 | 0.42 |
| ▸ | DRD3 | P35462 | 6/20 | 0.42 |
| ▸ | DRD4 | P21917 | 5/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21947692 | 0.84 | MAOA (0.55) | MAOAMAOBDRD1DRD5SLC6A4 | |
| SCHEMBL218317 | 0.77 | MAOA (0.59) | MAOAMAOBDRD1DRD5SLC6A4 | |
| SCHEMBL30561544 | 0.77 | MAOA (0.59) | MAOAMAOBDRD1DRD5SLC6A4 | |
| Hydrochloric Acid SCHEMBL4521948 | 0.75 | MAOA (0.60) | MAOAMAOBDRD1DRD5SLC6A4 | |
| SCHEMBL2616785 | 0.74 | MAOA (0.61) | MAOAMAOBDRD1DRD5SLC6A4 | |
| SCHEMBL12158830 | 0.73 | DRD1 (0.76) | MAOAMAOBDRD1DRD5DRD2 | |
| SCHEMBL21393017 | 0.73 | MAOA (0.59) | MAOAMAOBDRD1DRD5SLC6A4 | |
| SCHEMBL17721295 | 0.73 | MAOA (0.59) | MAOAMAOBDRD1DRD5SLC6A4 | |
| SCHEMBL6883015 | 0.73 | MAOA (0.59) | MAOAMAOBDRD1DRD5SLC6A4 | |
| SCHEMBL12363785 | 0.73 | MAOA (0.59) | MAOAMAOBDRD1DRD5SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020102576-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |
| WO-2019023147-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | IFM Tre, Inc. (US) | 2019-01-31 | — | — | WO | disclosed |