Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 4/20 | 0.55 |
| ▸ | MAOB | P27338 | 4/20 | 0.55 |
| ▸ | DRD1 | P21728 | 8/20 | 0.50 |
| ▸ | DRD5 | P21918 | 8/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 6/20 | 0.43 |
| ▸ | DRD3 | P35462 | 6/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20692240 | 0.84 | MAOA (0.53) | MAOAMAOBDRD1DRD5SLC6A4 | |
| SCHEMBL20892190 | 0.78 | HTR2A (0.47) | HTR2AHTR2CHTR2B | |
| SCHEMBL6369708 | 0.78 | HRH3 (0.48) | DRD1DRD2DRD3HTR2AHTR2C | |
| SCHEMBL23772573 | 0.77 | NPC1 (0.48) | HTR2AHTR2CHTR2B | |
| SCHEMBL8483178 | 0.77 | NPC1 (0.44) | HTR2AHTR2CHTR2B | |
| SCHEMBL20883600 | 0.76 | ESR2 (0.64) | HTR2AHTR2CHTR2B | |
| SCHEMBL19480257 | 0.76 | NOTUM (0.59) | HTR2AHTR2CHTR2B | |
| SCHEMBL22543812 | 0.76 | CA7 (0.54) | HTR2AHTR2CHTR2B | |
| SCHEMBL2616785 | 0.76 | MAOA (0.61) | MAOAMAOBDRD1DRD5SLC6A4 | |
| SCHEMBL10350537 | 0.75 | NOTUM (0.50) | DRD2HTR2AHTR2CHTR2BDRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081450-A1 | BIFUNCTIONAL COMPOUNDS FOR DEGRADING BTK VIA UBIQUITIN PROTEOSOME PATHWAY | NURIX THERAPEUTICS, INC. (US) | 2020-04-23 | — | — | WO | disclosed |