Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | ALPG | P10696 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 6/20 | 0.49 |
| ▸ | RAB9A | P51151 | 6/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2069336 | 0.82 | NPC1 (0.64) | TDP1L3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2069565 | 0.69 | EDNRB (0.45) | L3MBTL1NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL29993511 | 0.69 | GRM5 (0.47) | TDP1L3MBTL1ALPGGRM5MAPT | |
| SCHEMBL711648 | 0.69 | GRM5 (0.47) | TDP1L3MBTL1ALPGGRM5MAPT | |
| SCHEMBL5460248 | 0.67 | L3MBTL1 (0.61) | TDP1L3MBTL1ALPGNPC1RAB9A | |
| SCHEMBL19744921 | 0.67 | SMN1; SMN2 (0.41) | TDP1L3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30753710 | 0.66 | ALDH1A1 (0.50) | TDP1L3MBTL1ALPGGRM5MAPT | |
| SCHEMBL28364062 | 0.66 | TDP1 (0.45) | TDP1L3MBTL1ALPGGRM5MAPT | |
| SCHEMBL28101221 | 0.66 | MAOB (0.50) | TDP1L3MBTL1ALPGSMN1; SMN2MAPT | |
| SCHEMBL13114296 | 0.66 | MAPT (0.83) | L3MBTL1NPC1RAB9ASMN1; SMN2GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7906546-B2 | Tetrahydrocarbazoles and derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-03-15 | — | — | US | disclosed |
| US-20100216833-A1 | TETRAHYDROCARBAZOLES AND DERIVATIVES | DEHMLOW HENRIETTA | 2010-08-26 | — | — | US | disclosed |
| EP-1732892-B1 | TETRAHYDROCARBAZOLES AND DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2008-09-17 | — | — | EP | disclosed |
| EP-1732892-A1 | TETRAHYDROCARBAZOLES AND DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005092856-A1 | TETRAHYDROCARBAZOLES AND DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-10-06 | — | — | WO | disclosed |
| US-20050215577-A1 | Tetrahydrocarbazoles and derivatives | HOFFMANN-LA ROCHE INC. | 2005-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216833-A1 | TETRAHYDROCARBAZOLES AND DERIVATIVES | NR1H3, NR1H2, NR1H4 | TDP1 3388/4885L3MBTL1 1276/4885ALPG 2781/4885 |
| US-20050215577-A1 | Tetrahydrocarbazoles and derivatives | NR1H3, NR1H2, NR1H4 | TDP1 3388/4885L3MBTL1 1276/4885ALPG 2781/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.