Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | TYMS | P04818 | 3/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.34 |
| ▸ | CDK2 | P24941 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6366561 | 0.81 | MAPT (0.58) | TDP1EGFRMAPTPABPC1MAPK1 | |
| SCHEMBL4732620 | 0.78 | MAPT (0.64) | TDP1ALOX15EGFRMAPTPABPC1 | |
| SCHEMBL15452132 | 0.76 | TDP1 (0.48) | TDP1ALOX15EGFRMAPTPABPC1 | |
| SCHEMBL4956547 | 0.75 | EGFR (0.37) | TDP1EGFRMAPTPABPC1MAPK1 | |
| SCHEMBL18328582 | 0.75 | CA1 (0.43) | TDP1ALOX15RAB9ASMN1; SMN2MAOA | |
| SCHEMBL29860722 | 0.75 | MAOA (0.61) | RAB9ASMN1; SMN2MAOADDB1CRBN | |
| SCHEMBL303302 | 0.75 | MAOA (0.61) | RAB9ASMN1; SMN2MAOADDB1CRBN | |
| SCHEMBL15580925 | 0.75 | MAOA (0.61) | RAB9ASMN1; SMN2MAOADDB1CRBN | |
| SCHEMBL4222182 | 0.74 | MAOA (0.59) | TDP1ALOX15EGFRMAPTPABPC1 | |
| SCHEMBL17590085 | 0.73 | MAOA (0.44) | TDP1ALOX15EGFRMAPTPABPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019021303-A1 | A NOVEL PROCESS FOR THE PREPARATION OF APREMILAST IN AMORPHOUS FORM | ALKEM LABORATORIES LIMITED (IN) | 2019-01-31 | — | — | WO | disclosed |