Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | CASP3 | P42574 | 1/20 | 0.56 |
| ▸ | AHR | P35869 | 1/20 | 0.50 |
| ▸ | CCNE2 | O96020 | 9/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 9/20 | 0.49 |
| ▸ | CDK2 | P24941 | 9/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.45 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.45 |
| ▸ | CDK4 | P11802 | 4/20 | 0.45 |
| ▸ | CCND1 | P24385 | 4/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL303302 | 1.00 | MAOA (0.61) | MAOAALDH1A1KDM4EHPGDGAA | |
| SCHEMBL29860722 | 1.00 | MAOA (0.61) | MAOAALDH1A1KDM4EHPGDGAA | |
| SCHEMBL705018 | 0.89 | MAOA (0.49) | MAOAALDH1A1KDM4EHPGDGAA | |
| SCHEMBL17580121 | 0.89 | MAOA (0.49) | MAOAALDH1A1KDM4EHPGDGAA | |
| SCHEMBL17590085 | 0.85 | MAOA (0.44) | MAOAALDH1A1KDM4EHPGDGAA | |
| SCHEMBL3828974 | 0.83 | MAOA (0.51) | MAOAALDH1A1KDM4EHPGDGAA | |
| SCHEMBL15444503 | 0.83 | MAOA (0.43) | MAOAALDH1A1KDM4EHPGDGAA | |
| SCHEMBL18328582 | 0.83 | CA1 (0.43) | MAOAALDH1A1KDM4EHPGDGAA | |
| SCHEMBL20334273 | 0.80 | MAOA (0.90) | MAOAALDH1A1KDM4EHPGDGAA | |
| SCHEMBL29986841 | 0.79 | MAOA (0.87) | MAOAALDH1A1KDM4EHPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9642836-B2 | Isotopologues of isoindole derivatives | CELGENE CORPORATION (US) | 2017-05-09 | — | — | US | disclosed |
| US-20150258063-A1 | ISOTOPOLOGUES OF ISOINDOLE DERIVATIVES | AMGEN INC. | 2015-09-17 | — | — | US | disclosed |
| US-9045417-B2 | Isotopologues of isoindole derivatives | CELGENE CORPORATION (US) | 2015-06-02 | — | — | US | disclosed |
| US-8981117-B2 | Processes for the preparation of isoindole compounds and isotopologues thereof | CELGENE CORPORATION (US) | 2015-03-17 | — | — | US | disclosed |
| US-20140194485-A1 | ISOTOPOLOGUES OF ISOINDOLE DERIVATIVES | CELGENE CORPORATION (US) | 2014-07-10 | — | — | US | disclosed |
| US-20140081032-A1 | PROCESSES FOR THE PREPARATION OF ISOINDOLE COMPOUNDS AND ISOTOPOLOGUES THEREOF | CELGENE CORPORATION (US) | 2014-03-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140081032-A1 | PROCESSES FOR THE PREPARATION OF ISOINDOLE COMPOUNDS AND ISOTOPOLOGUES THEREOF | HPD, DHPS, IDH2 | MAOA 916/4885ALDH1A1 1488/4885KDM4E 2320/4885 |
| US-20140194485-A1 | ISOTOPOLOGUES OF ISOINDOLE DERIVATIVES | IDO1, CYP11B2, IDO2 | MAOA 556/4885ALDH1A1 1321/4885KDM4E 2562/4885 |
| US-20150258063-A1 | ISOTOPOLOGUES OF ISOINDOLE DERIVATIVES | IDO1, CYP11B2, IDO2 | MAOA 556/4885ALDH1A1 1321/4885KDM4E 2562/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.