SCHEMBL20698477

SCHEMBL20698477

c1ccc2c(c1)c1cc(-c3ncncn3)ccc1c1c(-c3ccc4c5cc(-c6ncncn6)ccc5c5cc(-c6ncncn6)ccc5c4c3)cccc21

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDO2 P48775 2/20 0.33
MAP4K4 O95819 2/20 0.33
ALOX5AP P20292 1/20 0.32
FEN1 P39748 1/20 0.32
KDM4E B2RXH2 1/20 0.32
TSHR P16473 3/20 0.32
ALDH1A1 P00352 2/20 0.32
MAPK1 P28482 2/20 0.32
HPGD P15428 1/20 0.32
CASP1 P29466 1/20 0.32
HIF1A Q16665 1/20 0.32
HSD17B10 Q99714 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
CYP1A2 P05177 2/20 0.31
CYP3A4 P08684 2/20 0.31
CYP2D6 P10635 2/20 0.31
CYP2C19 P33261 2/20 0.31
CLK4 Q9HAZ1 2/20 0.31
CYP2C9 P11712 1/20 0.31
TGFBR1 P36897 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23463383 0.88 PIK3CA (0.40) MAP4K4KDM4ETSHRALDH1A1MAPK1
SCHEMBL17229024 0.87 PARP1 (0.33) TDO2MAP4K4KDM4E
SCHEMBL30340690 0.87 PARP1 (0.33) TDO2MAP4K4KDM4E
SCHEMBL17229032 0.87 PARP1 (0.33) TDO2MAP4K4KDM4E
SCHEMBL17229027 0.87 PARP1 (0.33) TDO2MAP4K4KDM4E
SCHEMBL20698524 0.85 TDO2 (0.30) TDO2
SCHEMBL13615922 0.85 PARP1 (0.31) TDO2MAP4K4ALDH1A1HPGDHSD17B10
SCHEMBL13615765 0.85 PARP1 (0.31) TDO2MAP4K4ALDH1A1HPGDHSD17B10
SCHEMBL13615949 0.85 PARP1 (0.31) TDO2MAP4K4ALDH1A1HPGDHSD17B10
SCHEMBL20698337 0.81 CYP2A6 (0.33) TDO2MAP4K4KDM4ECLK4ACVR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190036043-A1 ORGANIC LIGHT-EMITTING DEVICE SAMSUNG DISPLAY CO., LTD. (KR) 2019-01-31 US disclosed