Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 8/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 8/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | PI4KA | P42356 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.47 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.47 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.47 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.47 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL566979 | 1.00 | ADORA2A (0.47) | ADORA2AADORA2BTP53CYP2C9NFKB1 | |
| SCHEMBL1851384 | 0.94 | ADORA2A (0.48) | ADORA2AADORA2BTP53CYP2C9NFKB1 | |
| SCHEMBL2197022 | 0.94 | ADORA2A (0.48) | ADORA2AADORA2BTP53CYP2C9NFKB1 | |
| SCHEMBL566598 | 0.94 | ADORA2A (0.48) | ADORA2AADORA2BTP53CYP2C9NFKB1 | |
| SCHEMBL29697253 | 0.94 | ADORA2A (0.48) | ADORA2AADORA2BTP53CYP2C9NFKB1 | |
| SCHEMBL11454503 | 0.90 | ADORA2A (0.57) | ADORA2AADORA2BTP53CYP2C9NFKB1 | |
| SCHEMBL565983 | 0.90 | ADORA2A (0.57) | ADORA2AADORA2BTP53CYP2C9NFKB1 | |
| SCHEMBL20275530 | 0.88 | YTHDC1 (0.60) | ADORA2AADORA2BTP53CYP2C9NFKB1 | |
| SCHEMBL2197420 | 0.87 | TP53 (0.48) | ADORA2AADORA2BTP53CYP2C9NFKB1 | |
| SCHEMBL29809280 | 0.86 | ADORA2A (0.55) | ADORA2AADORA2BTP53CYP2C9NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190038631-A1 | 6-AMINO-PURIN-8-ONE COMPOUNDS | GLAXOSMITHKLINE LLC | 2019-02-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190038631-A1 | 6-AMINO-PURIN-8-ONE COMPOUNDS | IFNG, IFNAR1, IRF3 | ADORA2A 78/4885ADORA2B 46/4885TP53 651/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.