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Ciclesonide

Ciclesonide

SCHEMBL2070189

CC(C)C(=O)OCC(=O)[C@@]12O[C@H](C3CCCCC3)O[C@@H]1C[C@H]1[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@@]12C.CCC(=O)OCC(=O)[C@@]1(OC(=O)CC)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@@]21C

nearest known ligand 0.70

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Ciclesonide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR3C1 known ✓ P04150 8/20 0.70
▸ PGR P06401 6/20 0.70
▸ ADORA3 P0DMS8 3/20 0.70
▸ CNR1 P21554 3/20 0.70
▸ NR1I2 O75469 3/20 0.70
▸ OPRK1 P41145 1/20 0.70
▸ CYP3A4 P08684 7/20 0.62
▸ USP2 O75604 6/20 0.62
▸ HIF1A Q16665 4/20 0.62
▸ AR P10275 2/20 0.62
▸ CHRM1 P11229 2/20 0.62
▸ TBXA2R P21731 1/20 0.62
▸ MAPT P10636 2/20 0.51
▸ DRD2 P14416 1/20 0.51
▸ OPRD1 P41143 1/20 0.51
▸ LMNA P02545 4/20 0.48
▸ CYP2C9 P11712 3/20 0.48
▸ KDM4E B2RXH2 1/20 0.48
▸ ALDH1A1 P00352 1/20 0.48
▸ TDP1 Q9NUW8 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ciclesonide SCHEMBL21456961 0.88 NR3C1 (0.65) NR3C1PGRADORA3CNR1NR1I2
Beclomethasone Dipropionate SCHEMBL266055 0.85 NR3C1 (0.65) NR3C1PGRADORA3CNR1NR1I2
Ciclesonide SCHEMBL14493775 0.83 NR3C1 (1.00) NR3C1PGRADORA3CNR1NR1I2
Ciclesonide SCHEMBL4782166 0.83 NR3C1 (1.00) NR3C1PGRADORA3CNR1NR1I2
Ciclesonide SCHEMBL1244607 0.83 NR3C1 (1.00) NR3C1PGRADORA3CNR1NR1I2
Ciclesonide SCHEMBL15830978 0.83 NR3C1 (1.00) NR3C1PGRADORA3CNR1NR1I2
Ciclesonide SCHEMBL3688 0.83 NR3C1 (1.00) NR3C1PGRADORA3CNR1NR1I2
Ciclesonide SCHEMBL1753411 0.83 NR3C1 (1.00) NR3C1PGRADORA3CNR1NR1I2
Ciclesonide SCHEMBL1244605 0.83 NR3C1 (1.00) NR3C1PGRADORA3CNR1NR1I2
Ciclesonide SCHEMBL139353 0.83 NR3C1 (1.00) NR3C1PGRADORA3CNR1NR1I2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8083127-B2 Slave wheel counter mechanism useable with an inhaler AVENTIS PHARMA LIMITED (GB) 2011-12-27 — — US disclosed
US-20110067695-A1 SLAVE WHEEL COUNTER MECHANISM USEABLE WITH AN INHALER AVENTIS PHARMA LIMITED (GB) 2011-03-24 — — US disclosed
US-7726555-B2 Slave wheel counter mechanism useable with an inhaler AVENTIS PHARMA LIMITED (GB) 2010-06-01 — — US disclosed
EP-1542750-B1 INHALER AVENTIS PHARMA LTD (GB) 2009-02-25 — — EP disclosed
US-20080066750-A1 SLAVE WHEEL COUNTER MECHANISM USEABLE WITH AN INHALER AVENTIS PHARMA LIMITED (GB) 2008-03-20 — — US disclosed
US-7322352-B2 Inhaler AVENTIS PHARMA LIMITED (GB) 2008-01-29 — — US disclosed
EP-1542750-A2 INHALER Aventis Pharma Limited (GB) 2005-06-22 — — EP disclosed
US-20040211420-A1 Inhaler AVENTIS PHARMA LIMITED (GB) 2004-10-28 — — US disclosed
WO-2004026380-A2 INHALER AVENTIS PHARMA LIMITED (GB) 2004-04-01 — — WO disclosed
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